N-2-ethyl-hexyl(4-dimethyl amino) pyridinium bromide | 127269-24-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-2-ethyl-hexyl(4-dimethyl amino) pyridinium bromide
• 英文别名: 4-(Dimethylamino)-1-(2-ethylhexyl)pyridin-1-ium bromide；1-(2-ethylhexyl)-N,N-dimethylpyridin-1-ium-4-amine;bromide
• CAS: 127269-24-3
• 化学式: Br*C₁₅H₂₇N₂
• 分子量: 315.297
• InChiKey: DIFDOPSLBYNPKJ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.26
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PROCESSES FOR PREPARING 4'AZIDO NUCLEOSIDE DERIVATIVES<br/>[FR] METHODES DE PREPARATION DE DERIVES DE 4'AZIDO NUCLEOSIDE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005000864A1

  公开（公告）日：2005-01-06

  A process for the preparation of a 4’-azido-2’,3’,5’-triacyl-nucleoside compound (I;B=B1; R1 is R1aCO-and R2 is R2aCO-) or a 4’-azidonucleoside compounds (I; B is B1 or B2 and R1 and R2 are hydrogen and acid addition salts thereof) wherein R1a and R2a are independently C1-10 alkyl or phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro or cyano and R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-3 haloalkyl and halogen, comprising contacting a 5’-iodo compound II with a peracid, R2aC(O)OOH, an acid R2aC(O)OH and a phase transfer catalyst and interconverting a uridine B1 to a cytosine B2. The present process provides the 4’-azidonucleosides safely and selectively in high purity with increased efficiency.

  一种制备4'-偶氮-2'，3'，5'-三酰基-核苷化合物（I；B=B1；R1为R1aCO-，R2为R2aCO-）或4'-偶氮核苷化合物（I；B为B1或B2，R1和R2为氢及其酸盐）的方法，其中R1a和R2a独立地为C1-10烷基或苯基，可选地取代为1至3个来自烷基、烷氧基、卤素、硝基或氰基的取代基，R3选自氢、C1-6烷基、C1-3卤代烷基和卤素组成，包括将5'-碘化合物II与过氧酸、R2aC（O）OOH、酸R2aC（O）OH和相转移催化剂接触，将尿苷B1互变为胞嘧啶B2。该过程以提高效率安全、选择性地提供高纯度的4'-偶氮核苷化合物。
• [DE] VERFAHREN ZUR HERSTELLUNG VON 4,6-DICHLOR-5-FLUORPYRIMIDIN<br/>[EN] METHOD FOR PRODUCING 4,6-DICHLORO-5-FLUOROPYRIMIDINE<br/>[FR] PROCEDE DE FABRICATION DE 4,6-DICHLORO-5-FLUOROPYRIMIDINES
  申请人：BAYER CROPSCIENCE AG

  公开号：WO2003106432A1

  公开（公告）日：2003-12-24

  Die Erfindung betrifft ein Verfahren zur Herstellung von 4,6-Dichlor-5-fluor-pyrimidin.

  这是一种制备4,6-二氯-5-氟嘧啶的方法。
• Method for producing 2-(hydroxyphenyl)-2-(alkoxyimino)-n-methylacetamide derivatives
  申请人：——

  公开号：US20040199014A1

  公开（公告）日：2004-10-07

  The invention relates to a novel process for preparing (2E)-2-(hydroxyphenyl)-2-(alkoxyimino)-N-methylacetamides.

  本发明涉及一种制备（2E）-2-（羟基苯基）-2-（烷氧基亚胺基）-N-甲基乙酰胺的新工艺。
• Processes for preparing 4'-azido-nucleoside derivatives
  申请人：Connolly Joseph Terrence

  公开号：US20050038240A1

  公开（公告）日：2005-02-17

  A process for the preparation of a 4′-azido-2′,3′,5′-triacyl-nucleoside compound (I; B=B1; R 1 is R 1a CO— and R 2 is R 2a CO—) or a 4′-azidonucleoside compounds (I; B is B1 or B2 and R 1 and R 2 are hydrogen and acid addition salts thereof) wherein R 1a and R 2a are independently C 1-10 alkyl or phenyl optionally substituted with 1 to 3 substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro or cyano and R 3 is selected from the group consisting of hydrogen, C 1-6 alkyl, C 1-3 haloalkyl and halogen, comprising contacting a 5′-iodo compound II with a peracid, R 2a C(O)OOH, an acid R 2a C(O)OH and a phase transfer catalyst and interconverting a uridine B1 to a cytosine B2. The present process provides the 4′-azidonucleosides safely and selectively in high purity with increased efficiency.

  一种制备4'-偶氮基-2'、3'、5'-三酰基-核苷化合物(I；B=B1；R1为R1aCO-，R2为R2aCO-）或4'-偶氮基-核苷化合物(I；B为B1或B2，R1和R2为氢，以及它们的酸加成盐），其中R1a和R2a分别独立地为C1-10烷基或苯基，可选地被1至3个取自烷基、烷氧基、卤素、硝基或氰基的取代基取代，R3选自羟基、C1-6烷基、C1-3卤代烷基和卤素，包括将5'-碘化合物II与过酸、R2aC（O）OOH、酸R2aC（O）OH和相转移催化剂接触，并将尿苷B1互变为胞嘧啶B2。本发明提供了一种安全、选择性高、纯度高、效率提高的制备4'-偶氮基-核苷化合物的方法。
• Verfahren zur Herstellung von Methacryloxy-oder Acryloxygruppen enthaltende Organosilanen
  申请人：HÜLS AKTIENGESELLSCHAFT

  公开号：EP0483480A1

  公开（公告）日：1992-05-06

  Es wird ein Verfahren zur Herstellung von Methacryloxy- oder Acryloxygruppen enthaltenden Organosilanen durch Umsetzung von Alkalimethacrylaten oder -acrylaten mit Chloralkylsilanen beschrieben. Als Phasentransfer-Katalysator werden dabei quaternäre Pyridiniumhalogenide eingesetzt.

  描述了一种通过碱金属甲基丙烯酸酯或丙烯酸酯与氯烷基硅烷反应制备含有甲基丙烯酰氧基或丙烯酰氧基基团的有机硅烷的工艺。季铵盐卤化物被用作相转移催化剂。