N,N-Diethyl-3-imino-8-methyl-3H-phenoxazin-7-amine | 13117-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: N,N-Diethyl-3-imino-8-methyl-3H-phenoxazin-7-amine
• 英文别名: N,N-diethyl-7-imino-2-methylphenoxazin-3-amine
• CAS: 13117-55-0
• 化学式: C₁₇H₁₉N₃O
• 分子量: 281.35
• InChiKey: WBARPMJDSAXUDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• METHOD OF MEASUREMENT OF MATERIAL AND TESTPIECE
  申请人：KABUSHIKI KAISHA KYOTO DAIICHI KAGAKU

  公开号：EP0860695A1

  公开（公告）日：1998-08-26

  A method of measuring an analyte, comprising a step of measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein a layered inorganic compound is caused to exist in the reaction system including the formation reaction of the detectable substance, whereby high-sensitivity measurement is made possible, the detectable substance can be stabilized to improve accuracy of the measurement, a rate of a chemical reaction is increased to enable quick measurement, and high-sensitivity measurement is made possible even in a reaction system which forms an insoluble substance. Also, it can be provided an analytical testing piece for measuring an analyte, by measuring a detectable substance by using a reaction system including a formation reaction of the detectable substance based on a chemical reaction of the analyte contained in a sample, wherein the testing piece comprises at least one test portion having a detection portion for detecting the detectable substance and contains a layered inorganic compound at least in the test portion, whereby diffusion and elution of a dyestuff or the like is prevented, more sensitive and accurate simple analysis is made possible, and easy handling is possible.

  一种测量被分析物的方法，包括以下步骤：根据样品中含有的被分析物的化学反应，使用包括可检测物质的形成反应的反应系统测量可检测物质，其中在包括可检测物质的形成反应的反应系统中导致层状无机化合物的存在、从而实现高灵敏度测量，稳定可检测物质以提高测量精度，提高化学反应速率以实现快速测量，即使在形成不溶性物质的反应体系中也能实现高灵敏度测量。此外，还可以提供一种用于测量被分析物的分析检测件，通过使用反应系统测量可检测物质，该反应系统包括基于样品中所含被分析物的化学反应的可检测物质的形成反应，其中检测件包括至少一个测试部分，该测试部分具有用于检测可检测物质的检测部分，并且至少在测试部分中包含分层无机化合物，从而防止染料或类似物的扩散和洗脱，实现更灵敏、更准确的简单分析，并且易于处理。
• SPECIMEN HAVING CAPABILITY OF SEPARATING SOLID COMPONENT
  申请人：ARKRAY, Inc.

  公开号：EP1271143A1

  公开（公告）日：2003-01-02

  A test strip having the capability of separating blood cells from whole blood, wherein it has a porous reagent layer comprising beads, an inorganic gel and a reagent that causes a detectable reaction with a substance to be detected, and a substrate that supports the reagent layer, wherein the beads are adhered to each other with the inorganic gel, and interstices are formed between the beads to trap a solid. The test strip can thus be used for separating blood cells from a whole blood including blood cells and plasma and detecting a substance to be detected, such as glucose, contained in plasma. The use of the test strip allows the measurement of a substance to be detected even by measurement of a transmitted light, the exhibition of good oxygen permeability, and thus can be used for measuring a substance to be detected with improved accuracy.

  一种能从全血中分离血细胞的试纸，它具有一个多孔试剂层，该试剂层由微珠、无机凝胶和能与待检测物质发生可检测反应的试剂组成，以及一个支撑试剂层的基板，其中微珠与无机凝胶相互粘附，微珠之间形成间隙以吸附固体。因此，该试纸可用于从包括血细胞和血浆在内的全血中分离出血细胞，并检测血浆中的待检测物质，如葡萄糖。使用该试纸甚至可以通过透射光的测量来检测某种物质，显示出良好的透氧性，从而可以更准确地测量某种待检测物质。
• BIOSENSOR AND METHOD FOR PREPARATION THEREOF
  申请人：Arkray, Inc.

  公开号：EP1679508A1

  公开（公告）日：2006-07-12

  The present invention provides a biosensor that can prevent a mediator from being affected by oxygen, thereby allowing an analyte in a sample solution to be measured rapidly and easily with high accuracy. The biosensor can be produced by providing a substrate having electrodes, applying a solvent containing a mediator, a surfactant, a buffer, and a layered inorganic compound to surfaces of the electrodes to form an inorganic gel layer for preventing natural oxidation of the mediator, and forming an enzyme reagent layer containing an oxidoreductase on the inorganic gel layer. In this biosensor, due to the inorganic gel layer, the mediator having been reduced by the reaction between an analyte and the oxidoreductase can be measured electrochemically, without being reoxidized by dissolved oxygen or the like.

  本发明提供了一种生物传感器，它可以防止介质受到氧气的影响，从而快速、简便、高精度地测量样品溶液中的分析物。该生物传感器的制作方法是：提供一个具有电极的基底，在电极表面涂抹含有介质、表面活性剂、缓冲剂和层状无机化合物的溶剂，以形成无机凝胶体层，防止介质自然氧化，并在无机凝胶体层上形成含有氧化还原酶的酶试剂层。在这种生物传感器中，由于无机凝胶体层的存在，被分析物与氧化还原酶反应还原的介质可以通过电化学方法进行测量，而不会被溶解氧或类似物重新氧化。
• BIOSENSOR AND PRODUCTION METHOD FOR SAME
  申请人：ARKRAY, Inc.

  公开号：EP3290523A1

  公开（公告）日：2018-03-07

  A biosensor includes electrodes that are formed on an insulation substrate, the electrodes including a working electrode and a counter electrode disposed side by side in a first direction such that one of the working electrode and the counter electrode is sandwiched by the other, a hydrophilic region that is continuously formed on the electrodes, that has higher hydrophilicity than a surrounding region thereof, that has first ends, in a second direction orthogonal to the first direction, disposed between both ends of the working electrode and between both ends of the counter electrode, and that has second ends, in the first direction, each disposed on a pair of working electrodes or a pair of counter electrodes, which are disposed on the outermost side, and a reagent layer that contains an enzyme and a mediator and that is disposed on the hydrophilic region.

  一种生物传感器包括在绝缘基板上形成的电极，电极包括在第一方向上并排设置的工作电极和对电极，使得工作电极和对电极中的一个被另一个夹住，在电极上连续形成的亲水区域，其亲水性高于其周围区域，具有第一端、在与第一方向正交的第二方向上，亲水区位于工作电极的两端和对电极的两端之间，在第一方向上，亲水区的第二端分别位于最外侧的一对工作电极或一对对电极上。
• Biosensor and production method for same
  申请人：ARKRAY, Inc.

  公开号：US10619178B2

  公开（公告）日：2020-04-14

  The disclosure relates to a biosensor including electrodes, a hydrophilic region or layer, and a reagent layer that contains an enzyme and a mediator, and methods of producing thereof.

  本公开涉及一种生物传感器，包括电极、亲水区或亲水层、含有酶和介质的试剂层及其生产方法。