2-[(2-{[2-(Dimethylamino)ethyl](methyl)amino}ethyl)(methyl)amino]ethan-1-ol | 74705-39-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(2-{[2-(Dimethylamino)ethyl](methyl)amino}ethyl)(methyl)amino]ethan-1-ol
• 英文别名: 2-[2-[2-(dimethylamino)ethyl-methylamino]ethyl-methylamino]ethanol
• CAS: 74705-39-8
• 化学式: C₁₀H₂₅N₃O
• 分子量: 203.33
• InChiKey: WVKTYUDLMQWYFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• N-heterocyclic inhibitors of TNF-alpha expression
  申请人：——

  公开号：US20020065270A1

  公开（公告）日：2002-05-30

  N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I: 1 Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-&agr; expression utilizing compounds of the present invention are also disclosed.

  抑制 p38 激酶从而阻断细胞因子产生的 N-杂环化合物已被披露。在一种实施例中，本发明的化合物由式 I 表示。还披露了利用本发明化合物的生产方法、药物组合物以及治疗与不当 p38 激酶活性或 TNF-α 表达相关的疾病的方法。
• Catalyst for production of a polyurethane resin and method for producing a polyurethane resin
  申请人：——

  公开号：US20030088046A1

  公开（公告）日：2003-05-08

  Polyurethane resins are produced by reacting a polyol with a polyisocyanate in the presence of an amine catalyst of one of the formulae: 1

  聚氨酯树脂是通过在一种胺催化剂的存在下，将聚醇与聚异氰酸酯反应而制得的，该胺催化剂的化学式之一为：1
• Catalyst for production of a polyurethane resin and method for producting a polyurethane resin
  申请人：Tosoh Corporation

  公开号：US20040147705A1

  公开（公告）日：2004-07-29

  A method for producing a polyurethane resin, which comprises reacting a polyol with a polyisocyanate in the presence of a catalyst selected from the group consisting of a catalyst (A) containing an amine compound of the following formula (1): 1 wherein each of R 1 and R 2 which are independent of each other, is a C 1-4 alkyl group, and A is a C 5-10 straight chain or branched chain alkylene group; a catalyst (B) containing an amine compound of the following formula (2): 2 a catalyst (C) containing an amine compound of the following formula (3): 3 a catalyst (D) containing a compound of the following formula (5): 4 wherein each of R 3 , R 4 and R 5 which are independent of one another, is a hydrogen atom or a C 1-4 alkyl group, R 6 is a hydrogen atom, a functional group of the following formula: 5 wherein R 7 is a hydrogen atom or a C 1-4 alkyl group, and p is an integer of from 1 to 3, or a 3-aminopropyl group, and an amine compound of the following formula (6): 6 wherein X is a nitrogen atom or an oxygen atom, each of R 8 and R 9 which are independent of each other, is a methyl group or a functional group of the following formula: 7 wherein R 10 is a hydrogen atom or a C 1-4 alkyl group, and q is an integer of from 1 to 3, and each of m and n is an integer of from 1 to 2, provided that when X is a nitrogen atom, R 8 and R 9 are not simultaneously methyl groups, and that when X is an oxygen atom, R 9 is a functional group of the following formula: 8 wherein R 10 is a hydrogen atom or a C 1-4 alkyl group, and q is an integer of from 1 to 3; and a catalyst (E) containing an amine compound of the following formula (7): 9 wherein each of R 11 , R 12 and R 13 which are independent of one another, is a hydrogen atom or a C 1-4 straight chain or branched chain alkyl group, and R 14 is a C 1-4 straight chain or branched chain alkylene group.

  一种制备聚氨酯树脂的方法，其包括在催化剂的存在下，将聚醇与聚异氰酸酯反应，所述催化剂从以下组中选择：催化剂（A）包含以下公式（1）的胺化合物：其中，R1和R2各自独立地是C1-4烷基，A是C5-10直链或支链烷基；催化剂（B）包含以下公式（2）的胺化合物：催化剂（C）包含以下公式（3）的胺化合物：催化剂（D）包含以下公式（5）的化合物：其中，R3、R4和R5各自独立地是氢原子或C1-4烷基，R6是氢原子，以下式子的功能基：其中，R7是氢原子或C1-4烷基，p是1到3之间的整数，或3-氨丙基基团，以及以下公式（6）的胺化合物：其中，X是氮原子或氧原子，R8和R9各自独立地是甲基或以下式子的功能基：其中，R10是氢原子或C1-4烷基，q是1到3之间的整数，m和n各自是1到2之间的整数，但当X是氮原子时，R8和R9不能同时为甲基，当X是氧原子时，R9是以下式子的功能基：其中，R10是氢原子或C1-4烷基，q是1到3之间的整数；以及催化剂（E）包含以下公式（7）的胺化合物：其中，R11、R12和R13各自独立地是氢原子或C1-4直链或支链烷基，R14是C1-4直链或支链烷基。
• Process for the production of flexible polyurethane foams
  申请人：Tosoh Corporation

  公开号：EP1312630A1

  公开（公告）日：2003-05-21

  Flexible polyurethane foams are produced by reacting a polyol and a polyisocyanate in the presence of a catalysts and other auxiliary agents, the process characterized in that a tin-based catalyst is not used. One process includes reacting a polyether polyol containing at least 5% by weight of an oxyethylene group in the chain and having a terminal secondary OH group, a toluene diisocyanate and/or a derivative, and one or more specified imidazole compounds, the process conducted in the absence of a tin-based catalyst.

  柔性聚氨酯泡沫塑料是通过多元醇和多异氰酸酯在催化剂和其他辅助剂的存在下发生反应而生产的，该工艺的特点是不使用锡基催化剂。一种工艺包括使一种在链中含有至少 5%（按重量计）氧乙烯基并具有末端仲羟基的聚醚多元醇、一种甲苯二异氰酸酯和/或衍生物以及一种或多种特定咪唑化合物发生反应，该工艺在无锡基催化剂的情况下进行。
• HYDROXYALKYLATED POLYALKYLENEPOLYAMINE COMPOSITION, METHOD FOR PRODUCING SAME AND METHOD FOR PRODUCING POLYURETHANE RESIN USING SUCH HYDROXYALKYLATED POLYALKYLENEPOLYAMINE COMPOSITION
  申请人：TOSOH CORPORATION

  公开号：EP1813599A1

  公开（公告）日：2007-08-01

  Disclosed is a novel hydroxyalkylated polyalkylene polyamine composition, and a method for preparing the hydroxyalkylated polyalkylene polyamine composition at low cost. Further disclosed is a method for producing a polyurethane resin by using the hydroxyalkylated polyalkylene polyamine composition containing at least two hydroxyalkylated polyalkylene polyamines represented by the following general formula (1): In the formula (1), R1 to R5 are independently a C1 to C3 alkyl group or a substituent represented by the following general formula (2): wherein R6 and R7 are independently a hydrogen atom or a C1 to C4 alkyl group, and p is an integer from 1 to 3; and R5 and R1, R2, R3, or R4 may arbitrarily bond together to form a ring; at least one of R1 to R5 is a substituent represented by the general formula (2) but all of R1 to R5 cannot be substituents represented by the general formula (2) at the same time; n and m are independently an integer from 1 to 5; and a is an integer from 1 to 6.

  本发明公开了一种新型羟烷基化聚亚烷基多胺组合物，以及一种低成本制备羟烷基化聚亚烷基多胺组合物的方法。还公开了一种使用羟烷基化聚亚烷基多胺组合物生产聚氨酯树脂的方法，该组合物至少含有两种由以下通式（1）表示的羟烷基化聚亚烷基多胺： 在式(1)中，R1 至 R5 独立地为 C1 至 C3 烷基或由下式(2)代表的取代基： 其中 R6 和 R7 独立地为氢原子或 C1 至 C4 烷基，p 为 1 至 3 的整数；R5 和 R1、R2、R3 或 R4 可任意地键合在一起形成环；R1 至 R5 中至少有一个是通式（2）所代表的取代基，但 R1 至 R5 不能全部同时为通式（2）所代表的取代基；n 和 m 独立地为 1 至 5 的整数；a 为 1 至 6 的整数。