[3-(4-甲基-哌嗪-1-基)-丙基]-胍 | 90795-66-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: [3-(4-甲基-哌嗪-1-基)-丙基]-胍
• 英文名称: [3-(4-methyl-piperazin-1-yl)-propyl]-guanidine
• 英文别名: N-[3-(4-methyl-piperazin-1-yl)-propyl]-guanidine；<3-(4-Methylpiperazino)propyl>guanidin；1-Methyl-4-(3-guanidinopropyl)-piperazin；2-[3-(4-methylpiperazin-1-yl)propyl]guanidine
• CAS: 90795-66-7
• 化学式: C₉H₂₁N₅
• mdl: MFCD20485307
• 分子量: 199.299
• InChiKey: BKTZIZAWQMGVPX-UHFFFAOYSA-N

物化性质

• 沸点：
  314.8±52.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  70.9
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  、 [3-(4-甲基-哌嗪-1-基)-丙基]-胍 、 Isopropyl-[4-(2-isopropylpyrazolo[1,5-a]pyridin-3-yl)-pyrimidin-2-yl]-amine 生成 AV 1135
  参考文献：
  名称：

  SUBSTITUTED PYRAZOLO[1,5-a] PYRIDINE COMPOUNDS AND THEIR METHODS OF USE

  摘要：

  本发明涉及取代的吡唑并[1,5-a]吡啶及其合成和使用的相关方法。

  公开号：

  US20100035920A1
• 作为产物：
  描述：

  1-(2-氰乙基)-4-甲基哌嗪 在 镍 sodium hydroxide 、 氨 、 氢气 作用下， 以 甲醇 、 水 为溶剂， 生成 [3-(4-甲基-哌嗪-1-基)-丙基]-胍
  参考文献：
  名称：

  Design, synthesis and biological evaluation of 1,3-diaminopropanes: a new class of polyamine analogs as leishmanicidal agents

  摘要：

  Analogs of I,S-diaminopropane as inhibitors for the growth of Leishmania donovani have been synthesized and evaluated,for their antileishmanial activity. Of the many active compounds, 1-(3-N,N-bis methoxycarbonyl guanidino)propyl-4-methylpiperidine piperazine (4e,f) exhibited significant in vivo inhibitory efficacy against L. donovani by oral and intraperitoneal route of administration. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00087-5

文献信息

• THIENOPYRIMIDINES
  申请人：Hoelzemann Guenter

  公开号：US20110028472A1

  公开（公告）日：2011-02-03

  Novel thienopyrimidines of the formula (I), in which R 1 , R 2 and X have the meanings indicated in Claim 1 , are inhibitors of TGF-beta receptor kinase, and can be employed, inter alia, for the treatment of tumours.

  化合物(I)的新噻吩嘧啶类化合物，在其中R1、R2和X具有权利要求书中指示的含义，是TGF-beta受体激酶的抑制剂，可用于治疗肿瘤。
• [EN] PYRADAZINE COMPOUNDS AS GSK-3 INHIBITORS<br/>[FR] COMPOSES DE PYRADAZINE UTILES COMME INHIBITEURS DE GSK-3
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004035588A1

  公开（公告）日：2004-04-29

  The present invention relates generally to inhibitors of the kinases, such as GSK3, and more particularly to fused pyradazine compounds according to formula (I) and methods of their use.

  本发明通常涉及激酶抑制剂，如GSK3，更具体地涉及根据式(I)的融合吡啶并嘧啶化合物及其使用方法。
• Substituted pyrazolo [1,5-a] pyridine compounds and their methods of use
  申请人：Gaeta C.A. Federico

  公开号：US20080070912A1

  公开（公告）日：2008-03-20

  The present invention is directed to substituted pyrazolo[1,5-α]pyridines and related methods for their synthesis and use.

  本发明涉及取代的吡唑并[1,5-α]吡啶及其合成和使用的相关方法。
• SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
  申请人：Ali Syed M.

  公开号：US20100239525A1

  公开（公告）日：2010-09-23

  The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病的受试者来治疗癌症等细胞增殖性疾病的方法。
• Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use
  申请人：Avigen, Inc.

  公开号：US07585875B2

  公开（公告）日：2009-09-08

  The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use.

  本发明涉及取代的吡唑并[1,5-a]吡啶及其合成和使用的相关方法。