[3-[(2-苯基苯基)氨基甲酰]萘-2-基]磷酸二氢酯 | 140446-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: [3-[(2-苯基苯基)氨基甲酰]萘-2-基]磷酸二氢酯
• 中文别名: 3-羟基-N-(2'-联苯基)-萘-2-甲酰胺磷酸酯
• 英文名称: 3-Hydroxy-N-(2'-biphenyl)-2-naphthalenecarboxamide phosphate
• 英文别名: [3-[(2-phenylphenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate
• CAS: 140446-67-9
• 化学式: C₂₃H₁₈NO₅P
• 分子量: 419.373
• InChiKey: BHBCRWVSAUWUCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基联苯 在 五氯化磷 、 三氯化磷 作用下， 以 1,4-二氧六环 为溶剂， 反应 3.17h， 生成 [3-[(2-苯基苯基)氨基甲酰]萘-2-基]磷酸二氢酯
  参考文献：
  名称：

  Fluorescent Substrates for Potential Use in Enzyme-Linked Immunosorbent Assay of Membrane-Bound Nucleic Acids

  摘要：

  A number of phosphorylated fluorochromes were synthesized and tested for the alkaline phosphatase-linked fluorescence assay of membrane-bound nucleic acids. 3-Hydroxy-N-2'-biphenyl-2-naphthalenecarboxamide phosphate ester (HBNP) was found to be the most suitable for the assay. Nonfluorescent HBNP is hydrolyzed by phospholipase bound to the probe DNA to the highly fluorescent 3-hydroxy-N,2'-biphenyl-2-naphthalenecarboxamide (HBN). HBN is insoluble enough in aqueous medium to precipitate on the nylon membrane. Spots containing as little as 5 fg of lambda DNA can be successfully detected on the membrane with HBNP.

  DOI：

  10.1021/ac00080a022

文献信息

• Methods for cloning and manipulating genomes
  申请人：CODEX DNA, INC.

  公开号：US10975378B2

  公开（公告）日：2021-04-13

  Compositions and methods are disclosed herein for cloning a synthetic or a semi-synthetic donor genome in a heterologous host cell. In one embodiment, the donor genome can be further modified within a host cell. Modified or unmodified genomes can be further isolated from the host cell and transferred to a recipient cell. Methods disclosed herein can be used to alter donor genomes from intractable donor cells in more tractable host cells.

  本文公开了在异源宿主细胞中克隆合成或半合成供体基因组的组合物和方法。在一个实施方案中，供体基因组可在宿主细胞内进一步修饰。修改或未修改的基因组可进一步从宿主细胞中分离出来并转移到受体细胞中。本文公开的方法可用于在更易处理的宿主细胞中改变难以处理的供体细胞的供体基因组。
• Methods and nucleic acid probes for molecular genetic analysis of polluted environments and environmental samples
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：US20020150887A1

  公开（公告）日：2002-10-17

  The present invention provides novel methods for analyzing a dominant level of a certain microorganism with a specific function in an environment by detecting and quantifying nucleic acids of the microorganism by a non-RI method. Novel nucleic acid probes and an environmental diagnostic kit comprising a non-RI-labeled probe are also provided. Methods, probes and kits for analyzing and diagnosing a polluted or contaminated environment, e.g., an oil-polluted environment, is provided.

  本发明提供了通过非 RI 方法检测和量化环境中具有特定功能的某种微生物的核酸，从而分析该微生物在环境中的优势水平的新方法。本发明还提供了新型核酸探针和包含非 RI 标记探针的环境诊断试剂盒。提供了用于分析和诊断污染或被污染环境（如石油污染环境）的方法、探针和试剂盒。
• Alu-derived exons and uses thereof for detection and treatment of genetic diseases
  申请人：Ast Gil

  公开号：US20050106584A1

  公开（公告）日：2005-05-19

  The present invention relates to polynucleotides comprising Alu-derived exons derived by alternative splicing from Alu elements, which are involved in cancer and genetic diseases. The present invention further relates to use of oligonucleotides for identification of the sequences associated with Alu exonization for diagnosis and treatment of cancer and genetic diseases.

  本发明涉及多核苷酸，其包含通过 Alu 元素的替代剪接衍生的 Alu 衍生外显子，这些外显子涉及癌症和遗传疾病。本发明进一步涉及寡核苷酸的用途，用于鉴定与 Alu 外显子相关的序列，以诊断和治疗癌症和遗传疾病。
• METHODS FOR CLONING AND MANIPULATING GENOMES
  申请人：Synthetic Genomics, Inc.

  公开号：EP2403944B1

  公开（公告）日：2017-06-28
• JPH0491799A
  申请人：——

  公开号：JPH0491799A

  公开（公告）日：1992-03-25