(1R,2S)-2-methyl-N-propylcyclopentan-1-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,2S)-2-methyl-N-propylcyclopentan-1-amine
• 化学式: C₉H₁₉N
• 分子量: 141.25
• InChiKey: IJEKTTQNVYRMSH-DTWKUNHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• NEK6 KINASE INHIBITORS USEFUL FOR THE TREATMENT OF SOLID TUMORS
  申请人：CONSIGLIO NAZIONALE DELLE RICERCHE

  公开号：US20210147395A1

  公开（公告）日：2021-05-20

  The mitotic kinases regulating the dynamics of centrosomes and the functions of the mitotic spindle are potential targets for the antitumour therapy. In the present invention some molecules with inhibitory activity on NEK6 have been identified. The present invention relates to such molecules and to the compositions including them for use as inhibitors of NEK6 in a method of treatment of tumours both in monotherapy and in combinations with other drugs.