N,N-Diethyl-N-methylhexadecan-1-aminium chloride | 88254-41-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-Diethyl-N-methylhexadecan-1-aminium chloride
• 英文别名: diethyl-hexadecyl-methylazanium;chloride
• CAS: 88254-41-5
• 化学式: C21H46ClN
• 分子量: 348.0
• InChiKey: RRGHSHZGBRAVGS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.96
• 重原子数：
  23
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] CBD PRODRUGS, COMPOSITIONS, AND METHODS OF ADMINISTERING CBD AND CBD PRODRUGS<br/>[FR] PROMÉDICAMENTS CBD, COMPOSITIONS ET PROCÉDÉS D'ADMINISTRATION DE CBD ET DE PROMÉDICAMENTS CBD
  申请人：KALYTERA THERAPEUTICS INC

  公开号：WO2018096504A1

  公开（公告）日：2018-05-31

  Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 are each independently selected from -H, -SO3Na, -PO(ONa)2, -PO(OCH2CH3), -CH2PO(ONa)2, -NO2, -(L)-valine ester, -(L)-N-methyl arginine ester, -α-guanidinoglutaric acid ester, -2-iminobiotin ester, -3- hydroxy anthranilic acid ester, -(L)-nitroarginine ester, -(L)- N5-(1-iminoethyl)-(L)- ornithine (NIO) ester, -(L)-N,N dimethylarginine ester, -(L)- N6-(1-iminoethyl)-(L)-lysine (NIL) ester, -(L)- N-monomethyl-(L)-arginine (NMMA) ester, -N-amino-(L)-arginine ester, -N-propyl-(L)-arginine ester, -S-methyl-(L)-thiocitrulline ester, -methyl-(L)-NIO ester, - vinyl -(L)-NIO ester, and -propenyl-(L)-NK) ester; and wherein when X is a direct bond, R1 and R2 are Formula (II).

  化合物的化学式（I），包括其立体异构体和盐，以及其组合物、治疗和预防方法，以及其制备方法：化学式（I）其中X为O或直接键；其中当X为O时，R1和R2分别独立选择自-H、-SO3Na、-PO(ONa)2、-PO(OCH2CH3)、-CH2PO(ONa)2、-NO2、-(L)-缬氨酸酯、-(L)-N-甲基精氨酸酯、-α-瓜氨酸戊二酸酯、-2-亚基生物素酯、-3-羟基蒽醌酸酯、-(L)-硝基精氨酸酯、-(L)-N5-(1-亚基乙基)-(L)-鸟氨酸（NIO）酯、-(L)-N,N-二甲基精氨酸酯、-(L)-N6-(1-亚基乙基)-(L)-赖氨酸（NIL）酯、-(L)-N-单甲基-(L)-精氨酸（NMMA）酯、-N-氨基-(L)-精氨酸酯、-N-丙基-(L)-精氨酸酯、-S-甲基-(L)-硫基瓜氨酸酯、-甲基-(L)-NIO酯、-乙烯基-(L)-NIO酯和-丙烯基-(L)-NK）酯；当X为直接键时，R1和R2为化学式（II）。
• Cosmetic
  申请人：Yoshida Kunihiko

  公开号：US20050271611A1

  公开（公告）日：2005-12-08

  This invention relates to cosmetic, in particular, relates to improvements of retaining performance and film-line feeling of makeup cosmetic for lips, eyelashes and skin, makeup cosmetic, and improvements of emulsion stability and dispersibility of powder in water-in-oil emulsion cosmetic. This invention is to provide cosmetic comprising a copolymer comprising specific acrylic acid monomer (A), specific polyoxyalkylene monomer (B) and specific organopolysiloxane monomer (C) as constituting monomers, wherein the content of monomer (A) is 20% by mass or more relative to the total amount of the constituting monomers.

  本发明涉及化妆品，特别是涉及改进唇部、睫毛和皮肤化妆品的保持性能和薄膜感，化妆品以及水油乳液化妆品中粉末的乳液稳定性和分散性的改进。本发明旨在提供一种化妆品，包括由特定丙烯酸单体（A）、特定聚氧烷单体（B）和特定有机聚硅氧烷单体（C）组成的共聚物作为构成单体，其中单体（A）的含量相对于构成单体的总量为20%或更高。
• [EN] METHODS AND COMPOSITIONS FOR TREATMENT OF PRADER-WILLI SYNDROME<br/>[FR] MÉTHODES ET COMPOSITIONS POUR LE TRAITEMENT DU SYNDROME DE PRADER-WILLI
  申请人：YISSUM RES DEV CO

  公开号：WO2017179058A1

  公开（公告）日：2017-10-19

  The present invention provides pharmaceutical compositions comprising a fatty acid amide of an amino acid as defined herein, such as oleoyl-α-methyl-serine, or a stereoisomer or salt thereof, for improving, i.e., increasing or preventing loss of, bone mineral density and/or treating osteoporosis in patients suffering from Prader-Willi syndrome; and methods of use.

  本发明提供了一种药物组合物，其中包括本文所定义的一种氨基酸脂肪酰胺，例如油酰-α-甲基-丝氨酸或其立体异构体或盐，用于改善，即增加或预防骨密度的流失，和/或治疗患有普拉德-威利综合症的患者的骨质疏松症；以及使用方法。
• Water-in-oil emulsion type cosmetics
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0331833A1

  公开（公告）日：1989-09-13

  A water-in-oil type emulsified composition contains a water-swellable clay mineral, a nonionic surfactant, an oil component, and water as the essential constituents or contains a water-swellable clay mineral, a quaternary ammonium salt type cationic surfactant, one or more kinds of polyoxyalkylene-modified organopolysiloxane, an aqueous phase, and an oil phase containing one or more kinds of organic silicone resin comprising units of the formula: RnSiO(4-n)/2 where R is a hydrocarbon group having 1 to 6 carbon atoms or a phenyl group, and n represents a value of 1.0 to 1.8. A water- and polyhydric alcohol-in-oil type emulsi­fied composition contains an oil phase containing a poly­oxyalkylene-modified organopolysiloxane, a water-swellable clay mineral, a quaternary ammonium salt type cationic surfactant and a silicone oil, water, and a polyhydric alcohol. The compositions are useful in the cosmetic art as a cosmetic or ointment base.

  一种油包水型乳化组合物含有一种水膨胀性粘土矿物、一种非离子表面活性剂、一种油组分和水作为基本成分，或含有一种水膨胀性粘土矿物、一种季铵盐型阳离子表面活性剂、一种或多种聚氧亚烷基改性有机聚硅氧烷、一种水相和一种或多种含有由式中单元组成的有机硅树脂的油相： RnSiO(4-n)/2 其中 R 是具有 1 至 6 个碳原子的烃基或苯基，n 代表 1.0 至 1.8 的值。一种油包水型和多元醇型乳化组合物的油相中含有聚氧亚烷基改性有机聚硅氧烷、水溶性粘土矿物、季铵盐型阳离子表面活性剂以及硅油、水和多元醇。这些组合物在化妆品领域可用作化妆品或软膏基质。
• O/W/O type multiple emulsion and method of preparing the same
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0782846A2

  公开（公告）日：1997-07-09

  In an oil- in- water- in- oil type multiple emulsion in which an oil- in- water emulsion is dispersed in a continuous outer oil phase, the outer oil phase contains an organophilic clay mineral. Since the addition of the organophilic clay mineral in the outer oil phase can prevent the inner oil phase combining with the outer oil phase, the excellent stability of the oil-in-water-in-oil type multiple emulsion over time can be obtained. Further, upon the using an oil-soluble compound, which can be easily oxidized, in the inner oil phase, this multiple emulsion system can prevent the compound from oxidation, and the excellent stability of the compound will be obtained. Also, since the coalescence between the inner oil phase and the outer oil phase is prevented and oils can be selected from quite wide range as an oil phase, it is possible to keep two kinds of oil components which have different properties independently from each other in one emulsion system stably. For example, when an oil- soluble material which is hard to dissolve in one special oil and an oil to which the material is soluble are added in one oil phase, whereas the special oil is added in the other oil phase, the material can be prevented from depositing crystals or separation while these components are made to coexist stably in one emulsion system.

  在水包油型复乳液中，水包油乳液分散在连续的外油相中，外油相中含有一种嗜有机粘土矿物。由于在外油相中添加了嗜有机粘土矿物，可以防止内油相与外油相结合，从而获得长期稳定性极佳的油包水油型多元乳液。 此外，在内层油相中使用易氧化的油溶性化合物时，这种多重乳液体系可以防止该化合物氧化，从而获得该化合物的优异稳定性。 此外，由于可以防止内油相和外油相之间的凝聚，而且可以从相当大的范围内选择油类作为油相，因此可以在一个乳液体系中稳定地保持两种性质各不相同的油类成分。例如，当在一种油相中加入难以溶解于一种特殊油的油溶性材料和该材料可溶解的油，而在另一种油相中加入特殊油时，可以防止材料沉淀结晶或分离，同时使这些成分在一个乳液体系中稳定共存。