3,4-Dichloropyrrolidine-2,5-dione | 71216-30-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3,4-Dichloropyrrolidine-2,5-dione
• CAS: 71216-30-3
• 化学式: C₄H₃Cl₂NO₂
• 分子量: 167.97
• InChiKey: PNOQDONZIUXXMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR PREPARATION OF PYROXASULFONE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE PYROXASULFONE
  申请人：PI INDUSTRIES LTD

  公开号：WO2020240392A1

  公开（公告）日：2020-12-03

  The present invention discloses a process for the preparation of Pyroxasulfone of Formula (I) or salt thereof. Particularly, the present invention discloses an improved process for the preparation of hydroxycarbonimidic dibromide compound of Formula (III) or salt thereof, wherein bromine anion is recycled by using a suitable oxidizing agent. Moreover, the present invention relates to a continuous flow process for preparing of compound of Formula (I) or salt thereof.

  本发明揭示了一种制备化合物Pyroxasulfone（化学式（I））或其盐的过程。特别地，本发明揭示了一种改进的制备化合物羟基碳酰亚胺二溴化物（化学式（III））或其盐的过程，其中溴负离子通过使用适当的氧化剂进行循环利用。此外，本发明涉及一种连续流程，用于制备化合物（化学式（I））或其盐。
• Semiconductive rubber foam
  申请人：MITSUI PETROCHEMICAL INDUSTRIES, LTD.

  公开号：EP0453085A2

  公开（公告）日：1991-10-23

  A semiconductive rubber foam having a volume resistivity that can be controlled to a practical level and retaining an initial softness even after the lapse of time, is obtained by foaming and curing a rubber composition comprising 100 parts by weight of a chlorinated ethylene/α-olefin copolymer rubber and 10 to 50 parts by weight of carbon black. The volume resistivity of this semiconductive rubber foam is in the range of from 10⁵ to 10¹¹ Ω-cm.

  一种体积电阻率可控制在实用水平、即使经过一段时间后仍能保持初始柔软度的半导电橡胶泡沫，是通过发泡和固化一种橡胶组合物而获得的，该组合物由 100 份（重量）氯化乙烯/α-烯烃共聚物橡胶和 10 至 50 份（重量）炭黑组成。这种半导体橡胶泡沫的体积电阻率范围为 10⁵ 至 10¹¹ Ω-cm。
• Lavatory cleansing and sanitizing blocks
  申请人：KIWI BRANDS INC

  公开号：EP0526437A1

  公开（公告）日：1993-02-03

  In a solid lavatory cleansing block or tablet containing a surfactant, a germicide agent or an oxidizing agent and fillers, the improvement which comprises said cleansing block having a stabilizer selected from the group consisting of mineral oil, silicone fluids and polybutene in an amount from about 0.1 to 8% by weight of the composition.

  在含有表面活性剂、杀菌剂或氧化剂和填料的固体盥洗室清洁块或片剂中，其改进包括所述清洁块具有选自矿物油、硅油和聚丁烯组成的组的稳定剂，其用量约为组合物重量的 0.1%至 8%。
• Compositions for inhibition of angiogenesis
  申请人：The Children's Medical Center Corporation

  公开号：EP2143444A9

  公开（公告）日：2013-02-27

  The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, anti-inflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.

  本发明包括一组能有效抑制血管生成的化合物。更具体地说，沙利度胺和各种相关化合物，如沙利度胺前体、类似物、代谢物和水解产物，已被证明可抑制血管生成和治疗血管生成导致的疾病状态。此外，抗炎药物，如类固醇和非甾体抗炎药物，可单独或与沙利度胺及相关化合物联合使用，抑制血管生成相关疾病。重要的是，这些化合物可以口服给药。
• Compositions for inhibition of anglogenesis
  申请人：The Children's Medical Center Corporation

  公开号：EP2143444A1

  公开（公告）日：2010-01-13

  The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogenesis and to treat disease states resulting from angiogenesis. Additionally, anti-inflammatory drugs, such as steroids and NSAIDs can inhibit angiogenesis dependent diseases either alone or in combination with thalidomide and related compounds. Importantly, these compounds can be administered orally.

  本发明包括一组能有效抑制血管生成的化合物。更具体地说，沙利度胺和各种相关化合物，如沙利度胺前体、类似物、代谢物和水解产物，已被证明可抑制血管生成和治疗血管生成导致的疾病状态。此外，抗炎药物，如类固醇和非甾体抗炎药物，可单独或与沙利度胺及相关化合物联合使用，抑制血管生成相关疾病。重要的是，这些化合物可以口服给药。