Tocris-0567 | 25597-07-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Tocris-0567
• 英文别名: [(2R)-3-carboxy-2-tetradecanoyloxypropyl]-trimethylazanium
• CAS: 25597-07-3
• 化学式: C21H42NO4+
• 分子量: 372.6
• InChiKey: PSHXNVGSVNEJBD-LJQANCHMSA-O

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

十四碳肉毒碱（Tetradecanoylcarnitine）是人体中的肉毒碱，参与长链脂肪酸的β型氧化。

靶点

Human Endogenous Metabolite（人类内源性代谢物）

文献信息

• METHODS AND COMPOSITIONS FOR DIAGNOSING DEPRESSION
  申请人：Duke University

  公开号：EP3938528A1

  公开（公告）日：2022-01-19
• Method and systems for creating and screening patient metabolite profile to diagnose current medical condition, diagnose current treatment state and recommend new treatment regimen
  申请人：Kurek Itzhak

  公开号：US20190214145A1

  公开（公告）日：2019-07-11

  Disclosed are methods and systems for building a database of metabolite profiles correlated with disease states and treatment regiments, then defining an individual patient's metabolite profile, and then screening the patient's profile against the database to recommend potential effective treatment regimens.
• [EN] METHODS AND COMPOSITIONS FOR DIAGNOSING DEPRESSION<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR LE DIAGNOSTIQUE DE LA DÉPRESSION
  申请人：UNIV DUKE

  公开号：WO2020185580A1

  公开（公告）日：2020-09-17

  Described herein are methods and composition for diagnosing and evaluating the treatment of depression using one or more biomarker metabolites for the diagnosis and monitoring treatment efficacy. In one aspect, the biomarker metabolites can be used to screen subjects for the likelihood of developing depression, the diagnosis thereof, monitoring the efficacy of treatment, and evaluating a subject's propensity for responding to treatment.