5-ethoxy-[1]naphthol | 119196-78-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-ethoxy-[1]naphthol
• 英文别名: 5-Aethoxy-[1]naphthol；5-Ethoxynaphthalen-1-ol
• CAS: 119196-78-0
• 化学式: C₁₂H₁₂O₂
• 分子量: 188.226
• InChiKey: GFXOVMFSDVWIOO-UHFFFAOYSA-N

物化性质

• 沸点：
  347.5±15.0 °C(Predicted)
• 密度：
  1.158±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-ethoxy-[1]naphthol 在 偶氮二甲酸二异丙酯 、 戴斯-马丁氧化剂 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  阴离子-(π)n-π催化胶束

  摘要：

  阴离子-(π) n -π 催化胶束的引入扩大了与阴离子-π 催化相容的系统催化剂的集合，具有丰富的普遍重要性的主题。他们感兴趣的是在水中实现阴离子-π催化、阴离子-(π) n -π催化和阴离子-(π) n -π自催化。安装超分子化学经典来控制有限胶束空间内的底物结合和定位，以获得涌现的特性。

  DOI：

  10.1002/anie.202310393
• 作为产物：
  描述：

  硫酸二乙酯 、 1,5-二羟基萘 在 sodium hydroxide 作用下， 生成 5-ethoxy-[1]naphthol
  参考文献：
  名称：

  二羟基萘和一些衍生物作为汽油抗氧化剂

  摘要：

  DOI：

  10.1021/ie50547a048

文献信息

• Gram-positive carbapenem antibacterials and processes for their preparation
  申请人：Choi Woo-Baeg

  公开号：US20060074070A1

  公开（公告）日：2006-04-06

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供了β-甲基碳青霉烯化合物和制药组合物，可用于治疗细菌感染，并提供了使用这些化合物和/或组合物治疗此类感染的方法。本发明包括向需要此类治疗的宿主施用β-碳青霉烯化合物或盐和/或前药的有效量。本发明还属于合成有机化学领域，特别提供了一种改进的β-甲基碳青霉烯合成方法，其可用作抗菌剂。
• GRAM-POSITIVE CARBAPENEM ANTIBACTERIALS AND PROCESSES FOR THEIR PREPARATION
  申请人：Choi Woo-Baeg

  公开号：US20100075945A1

  公开（公告）日：2010-03-25

  The present invention provides β-methyl carbapenem compounds and pharmaceutical compositions useful in the treatment of bacterial infections and methods for treating such infections using such compounds and/or compositions. The invention includes administering an effective amount of a carbapenem compound or salt and/or prodrug thereof to a host in need of such a treatment. The present invention is also in the field of synthetic organic chemistry and is specifically provides an improved method of synthesis of β-methyl carbapenems which are useful as antibacterial agents.

  本发明提供了β-甲基碳青霉烯化合物和制药组合物，可用于治疗细菌感染，并提供使用这些化合物和/或组合物治疗此类感染的方法。本发明包括向需要此类治疗的宿主投与有效量的碳青霉烯化合物或盐和/或前药。本发明还属于合成有机化学领域，特别提供了一种改进的β-甲基碳青霉烯化合物合成方法，该方法可用作抗菌剂。
• EPOXY COMPOUND, CURABLE COMPOSITION, AND CURED PRODUCT THEREOF
  申请人：DIC Corporation

  公开号：EP2557103A1

  公开（公告）日：2013-02-13

  A problem to be solved by the invention is to provide a novel epoxy resin exhibiting excellent performance with respect to heat resistance and low thermal expansibility of a cured product, a curable composition using the same, and a cured product having excellent heat resistance and low thermal expansibility. The curable composition contains an epoxy compound and a curing agent as essential components, a calixarene-type novel epoxy compound being used as the epoxy compound. The novel epoxy compound has a resin structure represented by structural formula 1 below (in the formula, R1s each independently represent a hydrogen atom, an alkyl group, or an alkoxy group, and n is a repeat unit and an integer of 2 to 10).

  本发明要解决的问题是提供一种在固化产品的耐热性和低热膨胀性方面表现优异的新型环氧树脂、一种使用该环氧树脂的固化组合物以及一种具有优异耐热性和低热膨胀性的固化产品。该固化组合物包含环氧化合物和固化剂作为基本成分，环氧化合物是一种萼片烯类新型环氧化合物。新型环氧化合物具有如下结构式 1 所表示的树脂结构（式中，R1s 分别独立地代表氢原子、烷基或烷氧基，n 代表重复单元和 2 至 10 的整数）。
• Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues
  作者：Yizhou Dong、Qian Shi、Huei-Chen Pai、Chieh-Yu Peng、Shiow-Lin Pan、Che-Ming Teng、Kyoko Nakagawa-Goto、Donglei Yu、Yi-Nan Liu、Pei-Chi Wu、Kenneth F. Bastow、Susan L. Morris-Natschke、Arnold Brossi、Jing-Yu Lang、Jennifer L. Hsu、Mien-Chie Hung、Eva Y.-H. P. Lee、Kuo-Hsiung Lee

  DOI：10.1021/jm1000858

  日期：2010.3.11

  Neo-tanshinlactone (1) and its previously reported analogues, such as 2, are potent and selective in vitro antibreast cancer agents. The synthetic pathway to 2 was optimized from seven to five steps, with a better overall yield. Structure-activity relationships studies on these compounds revealed some key molecular determinants for this family of antibreast agents. Several derivatives (19-21 and 24) exerted potent and selective antibreast cancer activity with IC50 values of 0.3, 0.2, 0.1, and 0.1 mu g/mL, respectively, against the ZR-75-1 cell lines. Compound 24 was 2- to 3-fold more potent than I against SK-BR-3 and ZR-75-1. Importantly, 21 exhibited high selectivity; it was 23 times more active against ZR-75-1 than MCF-7. Compound 20 had an approximately 12-fold ratio of SK-BR-3/MCF-7 selectivity. In addition, analogue 2 showed potent activity against it ZR-75-1 xenograft model, but not PC-3 and MDA-MB-231 xenografts, as well as high selectivity against breast cancer cell line compared with normal breast tissue-derived cell lines. Further development of lead compounds 19-21 and 24 as clinical trial candidates is warranted.
• NAPHTHALENE-RING RESIN, RESIN COMPOSITION, AND CURED PRODUCT THEREOF
  申请人：NIPPON KAYAKU KABUSHIKI KAISHA

  公开号：EP0644216B1

  公开（公告）日：1996-07-17