N-[3-(4-methylpiperazin-1-yl)propyl]-6-propylbenzo[b][1,4]benzothiazepine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并硫氮卓类
• 英文名称: N-[3-(4-methylpiperazin-1-yl)propyl]-6-propylbenzo[b][1,4]benzothiazepine-3-carboxamide
• 化学式: C₂₅H₃₂N₄OS
• mdl: MFCD26964364
• 分子量: 436.6
• InChiKey: YKEKLULEMZJKHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  73.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• CB-1 MODULATING COMPOUNDS AND THEIR USE
  申请人：Olsson Roger

  公开号：US20080090805A1

  公开（公告）日：2008-04-17

  Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).

  本文披露了一种化合物的结构式(I)。同时也披露了使用结构式(I)的化合物调节大麻素受体活性的方法。此外，还披露了一种治疗疾病或症状的方法，该疾病或症状可以通过给予调节大麻素受体的化合物得到缓解、改善或预防，包括确定需要该方法的受试者，并向该受试者施用结构式(I)的化合物的治疗有效量。本文还披露了包含结构式(I)的药物组合物。
• CB-1 modulating compounds and their use
  申请人：Olsson Roger

  公开号：US20070105819A1

  公开（公告）日：2007-05-10

  Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).

  本文公开了一种公式（I）的化合物。本文还公开了一种使用公式（I）的化合物调节大麻素受体活性的方法。此外，本文还公开了一种治疗疾病或病症的方法，该疾病或病症可以通过给予调节大麻素受体的化合物来缓解、改善或预防，包括识别需要该治疗的受试者，并向该受试者施用公式（I）化合物的治疗有效量。本文还公开了包含公式（I）的化合物的制药组合物。
• [EN] CB-1 MODULATING COMPOUNDS AND THEIR USE<br/>[FR] COMPOSES MODULATEURS DE CB-1 ET LEUR UTILISATION
  申请人：ACADIA PHARM INC

  公开号：WO2007047737A1

  公开（公告）日：2007-04-26

  [EN] Disclosed herein is a compound of Formula (I). Also disclosed herein is a method of modulating the activity of a cannabinoid receptor using a compound of Formula (I). Furthermore, disclosed herein is a method of treating a disease or condition that would be alleviated, improved or prevented by administration of a compound that modulates a cannabinoid receptor comprising identifying a subject in need thereof and administering to said subject a therapeutically effective amount of a compound of Formula (I). Also disclosed herein are pharmaceutical compositions comprising a compound of Formula (I).
  [FR] L'invention concerne un composé représenté par la formule (I). L'invention concerne également une méthode de modulation de l'activité d'un récepteur cannabinoïde à l'aide d'un composé représenté par la formule (I). De plus, l'invention concerne une méthode de traitement d'une maladie ou d'une pathologie pouvant être soulagée, améliorée ou prévenue par administration d'un composé qui module un récepteur cannabinoïde, consistant à identifier un sujet nécessitant un tel traitement et à administrer audit sujet une quantité thérapeutiquement efficace d'un composé représenté par la formule (I). L'invention concerne enfin des compositions pharmaceutiques comprenant un composé représenté par la formule (I).