4,4'-[Oxybis(methylene)]bis[2-methoxyphenol] | 2880-61-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4,4'-[Oxybis(methylene)]bis[2-methoxyphenol]
• 英文别名: 4-[(4-hydroxy-3-methoxyphenyl)methoxymethyl]-2-methoxyphenol
• CAS: 2880-61-7
• 化学式: C₁₆H₁₈O₅
• 分子量: 290.31
• InChiKey: LSKFRYMLGSVAPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Melanogenesis inhibitor and skin preparation containing the same
  申请人：Ishida Kenya

  公开号：US20060088485A1

  公开（公告）日：2006-04-27

  A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.

  一种黑色素生成抑制剂，其特征在于包含至少一种由下述通式（1）表示的香豆素醇，其中R为直链或支链烷基，具有3至18个碳原子，直链或支链烯基，具有3至18个碳原子，或是可选择性取代的脂环烷基。该黑色素生成抑制剂具有较高的稳定性和安全性，并具有较强的黑色素生成抑制效果；含有该黑色素生成抑制剂的皮肤制剂非常稳定、安全，具有足够的美白效果和治疗皮肤色素沉着的效果。
• REFRIGERANT COMPOSITIONS, REFRIGERANT AUXILIARY COMPOSITIONS AND USES THEREOF
  申请人：Takasago International Corporation

  公开号：EP1496095A1

  公开（公告）日：2005-01-12

  The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-1-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N,2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

  本发明的清凉感组合物通过将含有至少一种选自 1-薄荷醇、异薄荷醇、3-(1-薄荷氧基)丙烷-1,2-二醇、2-(1-薄荷氧基)乙烷-1-醇、3-(1-薄荷氧基)丙烷-1-醇、2-甲基-3-(1-薄荷氧基)丙烷-1,2-二醇、N-乙基-1-薄荷甲酰胺、对薄荷-3,8-二醇、1-薄荷乳酸酯和 2-异丙基-N,2,3-三甲基丁酰胺的化合物的清凉感物质与下述通式(I)代表的水杨酸酯（如水杨酸 2-羟乙基酯）结合而获得，可改善清凉感、和 2-异丙基-N,2,3-三甲基丁酰胺与以下通式（I）代表的水杨酸酯（如水杨酸 2-羟乙基酯）混合，可提高清凉感的强度和持久性，特别是含有 1-薄荷醇作为清凉感物质的清凉感组合物，可减轻 1-薄荷醇产生的刺激性香味。将清凉感组合物或含有清凉感组合物的香料组合物与食品和饮料、化妆品、盥洗用品、沐浴剂和药品等产品混合，可以得到有效发挥本发明清凉感组合物上述特点的产品。 其中 R 代表具有 1 至 18 个碳原子的烃基，该烃基可能具有取代基。
• PLASTER COMPRISING ANTIEDEMATOUS SUBSTANCES FOR THE TREATMENT OF BRUISING AND INJURY
  申请人：Kubica, Krzysztof

  公开号：EP3173066A1

  公开（公告）日：2017-05-31

  The invention relates to an innovative form of antiedematous substance application, in a form of plasters, comprising aluminum acetate-tartrate. Apart from aluminum acetate-tartrate (or another substance mentioned above), the plaster can comprise one or few other active substances having an adjunctive or enhancing effect with respect to aluminum acetate-tartrate. The plaster structure is based on a possibility of storing and controlled release of the biologically active substances. The active substances, depending to the plaster structure, may be subject to the modified (e.g. sustained) release. Therapeutic properties of the product result from the combination of all constituents of the given product. Analysis has also shown a synergistic effect.

  本发明涉及一种创新的抗风湿物质应用形式，以膏药的形式使用，其中包括酒石酸醋酸铝。 除了酒石酸铝（或上述另一种物质），膏药还可以包含一种或几种其他活性物质，这些活性物质对酒石酸铝具有辅助或增强作用。膏药结构的基础是可以储存和控制生物活性物质的释放。根据膏药结构的不同，活性物质可能会被改变（如持续）释放。产品的治疗特性来自于产品中所有成分的组合。分析还显示了协同效应。
• Cosmetic blends
  申请人：Symrise AG

  公开号：US11123272B2

  公开（公告）日：2021-09-21

  Suggested is a cosmetic blend, comprising or consisting of (a) at least one TRPV1 and/or TRPV3 modulator and (b1) at least one 1,2-alkandiol having 5 to 12 carbon atoms and/or (b2) at least one polyol having 3 to 12 carbon atoms and 3 to 6 hydroxyl groups.

  建议使用一种化妆品混合物，该混合物包含或组成如下：(a) 至少一种 TRPV1 和/或 TRPV3 调节剂和 (b1) 至少一种具有 5 至 12 个碳原子的 1,2-烷二醇和/或 (b2) 至少一种具有 3 至 12 个碳原子和 3 至 6 个羟基的多元醇。
• Refrigerant composition, refrigerant auxiliary compositions and uses thereof
  申请人：Ishida Kenya

  公开号：US20050129721A1

  公开（公告）日：2005-06-16

  The cool feeling composition of the present invention obtained by combining a cool feeling substance containing at least one compound selected from 1-menthol, isopulegol, 3-(1-menthoxy)propane-1,2-diol, 2-(1-menthoxy)ethan-1-ol, 3-(1-menthoxy)propan-1-ol, 2-methyl-3-(1-menthoxy)propane-1,2-diol, N-ethyl-l-menthylcarboxamide, p-menthane-3,8-diol, 1-menthyl lactate, and 2-isopropyl-N, 2,3-trimethylbutanamide with a salicylic acid ester represented by the following general formula (I), such as 2-hydroxyethyl salicylate, improves strength and persistency of cool feeling effect, particularly, those containing 1-menthol as the cool feeling substance can alleviate the irritant fragrance note resulting from 1-menthol. Mixing of the cool feeling composition or fragrance composition containing the same with products such as foods and drinks, cosmetics, toiletry products, bath agents, and pharmaceuticals can afford products wherein the above features of the cool feeling composition of the invention are effectively exerted. wherein R represents a hydrocarbon group having 1 to 18 carbon atoms which may has a substituent.

  本发明的清凉感组合物通过将含有至少一种选自 1-薄荷醇、异薄荷醇、3-(1-薄荷氧基)丙烷-1,2-二醇、2-(1-薄荷氧基)乙醇、3-(1-薄荷氧基)丙烷-1-醇、2-甲基-3-(1-薄荷氧基)丙烷-1,2-二醇、N-乙基-l-薄荷甲酰胺、对薄荷-3,8-二醇、1-薄荷乳酸酯和 2-异丙基-N,2,3-三甲基丁酰胺的化合物的清凉感物质与下述通式(I)代表的水杨酸酯(如水杨酸 2-羟乙基酯)相结合而获得，可改善清凉感、和 2-异丙基-N,2,3-三甲基丁酰胺与下一通式（I）所代表的水杨酸酯（如水杨酸 2-羟乙基酯）混合，可提高清凉感的强度和持久性，尤其是含有 1-薄荷醇作为清凉感物质的清凉感组合物，可减轻 1-薄荷醇所产生的刺激性香味。将清凉感组合物或含有清凉感组合物的香料组合物与食品和饮料、化妆品、盥洗用品、沐浴剂和药品等产品混合，可以得到有效发挥本发明清凉感组合物上述特点的产品。 其中 R 代表具有 1 至 18 个碳原子的烃基，该烃基可能具有取代基。