4-benzyloxy-2-butylphenol | 1445971-93-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-benzyloxy-2-butylphenol
• 英文别名: 2-Butyl-4-phenylmethoxyphenol
• CAS: 1445971-93-6
• 化学式: C₁₇H₂₀O₂
• 分子量: 256.345
• InChiKey: LUKZXBSVGXKULQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  toluene-4-sulfonic acid 2-(5-methyl-2-biphenyl-4-yl-oxazol-4-ly)ethyl ester 、 4-benzyloxy-2-butylphenol 、 2-{4-[2-(2-biphenyl-4-yl-5-methyl-oxazol-4-yl)-ethoxy]-phenoxy}-2-methyl-propionic acid 生成 4-[2-(4-benzyloxy-2-butylphenoxy)ethyl]-5-methyl-2-biphenyl-4-yl-oxazole
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• [EN] BIARYL-OXA(THIA)ZOLE DERIVATIVES AND THEIR USE AS PPARS MODULATORS<br/>[FR] DERIVES DE BIARYL-OXA(THIA)ZOLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DE PPAR
  申请人：LILLY CO ELI

  公开号：WO2001016120A1

  公开（公告）日：2001-03-08

  Compounds represented by Formula (I) wherein n is 2, 3, or 4; V is O or S; W is O, S, or SO2 and at least one R5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; are modulators of peroxisome proliferator activated receptors and are useful in the treatment of type II diabetes and of cardiovascular diseases.

  公式（I）所代表的化合物中，其中n为2、3或4；V为O或S；W为O、S或SO2，且至少有一个R5为取代或未取代的芳基或取代或未取代的杂环基；是过氧化物酶体增殖物激活受体的调节剂，并且在治疗2型糖尿病和心血管疾病方面有用。
• Modulators of peroxisome proliferator activated receptors
  申请人：Eli Lilly & Company Lily Corporate Center

  公开号：US20030045558A1

  公开（公告）日：2003-03-06

  The present invention is directed to compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof, and methods of making, methods of using and pharmaceutical compositions having compounds represented by Structural Formula I and pharmaceutically acceptable salts, solvates and hydrates thereof: 1 In Structural Formula I, n is 2, 3, or 4; V is O or S; W is O, S, or SO 2 ; R 1 is H, a C1-C4 alkyl, phenyl or trifluoromethyl; R 2 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, a cycloalkyl, or together with the phenyl to which they are bound form naphthyl or 1,2,3,4-tetrahydronaphthyl; R 3 are each, independently, H, a C1-C6 alkyl, an aryl-C1-C6 alkyl, a cycloalkyl-C1-C4 alkyl, an aryl, or a cycloalkyl; R4 are each, independently, H, a C1-C4 alkyl, an aryl, or benzyl; R 5 are each, independently, H, a substituted or unsubstituted aryl or a heteroaryl, provided that at least one R 5 is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and R 6 is H, a C1-C4 alkyl, or an aminoalkyl.

  本发明涉及结构式I所表示的化合物及其药学上可接受的盐、溶剂和水合物，以及制备方法、使用方法和含有结构式I所表示的化合物及其药学上可接受的盐、溶剂和水合物的药物组合物： 在结构式I中，n为2、3或4；V为O或S；W为O、S或SO2；R1为H、C1-C4烷基、苯基或三氟甲基；R2各自独立地为H、C1-C6烷基、芳基-C1-C6烷基、环烷基-C1-C4烷基、芳基、环烷基或与它们所连接的苯基一起形成萘基或1,2,3,4-四氢萘基；R3各自独立地为H、C1-C6烷基、芳基-C1-C6烷基、环烷基-C1-C4烷基、芳基或环烷基；R4各自独立地为H、C1-C4烷基、芳基或苄基；R5各自独立地为H、取代或未取代的芳基或杂环芳基，但至少有一个R5为取代或未取代的芳基或取代或未取代的杂环芳基；R6为H、C1-C4烷基或氨基烷基。
• BIARYL-OXA(THIA)ZOLE DERIVATIVES AND THEIR USE AS PPARS MODULATORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1206457A1

  公开（公告）日：2002-05-22
• US6417212B1
  申请人：——

  公开号：US6417212B1

  公开（公告）日：2002-07-09
• US6610696B2
  申请人：——

  公开号：US6610696B2

  公开（公告）日：2003-08-26