phenyl N-(6-ethyl-1,3-benzothiazol-2-yl)carbamate | 1417159-81-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: phenyl N-(6-ethyl-1,3-benzothiazol-2-yl)carbamate
• CAS: 1417159-81-9
• 化学式: C₁₆H₁₄N₂O₂S
• 分子量: 298.365
• InChiKey: XAINBQOLFUAUMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(对乙基苯基)-2-硫脲 在 吡啶 、 溴 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 6.0h， 生成 phenyl N-(6-ethyl-1,3-benzothiazol-2-yl)carbamate
  参考文献：
  名称：

  Synthesis of substituted benzo[d]thiazol-2-ylcarbamates as potential anticonvulsants

  摘要：

  A series of substituted benzo[d]thiazol-2-ylcarbamates 4a-g and 5a-g were synthesized and evaluated for anticonvulsant activity. The structures of the synthesized compounds were confirmed on the basis of their physical and spectral data. The compounds were evaluated for anticonvulsant activity using PTZ-induced convulsion and maximal electroshock models. The target compounds have shown significant activity in these models.

  DOI：

  10.1007/s00044-012-0434-y

文献信息

• Synthesis of substituted benzo[d]thiazol-2-ylcarbamates as potential anticonvulsants
  作者：Ashvini Navale、Smita Pawar、Meenakshi Deodhar、Amol Kale

  DOI：10.1007/s00044-012-0434-y

  日期：2013.9

  A series of substituted benzo[d]thiazol-2-ylcarbamates 4a-g and 5a-g were synthesized and evaluated for anticonvulsant activity. The structures of the synthesized compounds were confirmed on the basis of their physical and spectral data. The compounds were evaluated for anticonvulsant activity using PTZ-induced convulsion and maximal electroshock models. The target compounds have shown significant activity in these models.