(8S)-8-methyl-2-(3-methylbutyl)-6-(phenoxymethyl)-1,3,4,7,8,10-hexahydropyrano[4,3-c][1,6]naphthyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: (8S)-8-methyl-2-(3-methylbutyl)-6-(phenoxymethyl)-1,3,4,7,8,10-hexahydropyrano[4,3-c][1,6]naphthyridine
• 化学式: C₂₄H₃₂N₂O₂
• 分子量: 380.53
• InChiKey: VRSOKMREWFZDNW-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  34.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-3-[N-(3-methylbutyl)-[N-4-(6-phenoxyhex-4-yn-2-yloxy)but-2-ynyl]amino]propanenitrile 在 carbon monoxide,cobalt,cyclopenta-1,3-diene 作用下， 以 氯苯 为溶剂， 反应 0.25h， 以88%的产率得到(8S)-8-methyl-2-(3-methylbutyl)-6-(phenoxymethyl)-1,3,4,7,8,10-hexahydropyrano[4,3-c][1,6]naphthyridine
  参考文献：
  名称：

  Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations

  摘要：

  Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1,6-naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the preparation of a collection of these compounds.

  DOI：

  10.1021/ol0625280

文献信息

• Synthesis of 5,6,7,8-Tetrahydro-1,6-naphthyridines and Related Heterocycles by Cobalt-Catalyzed [2 + 2 + 2] Cyclizations
  作者：Ya Zhou、John A. Porco、John K. Snyder

  DOI：10.1021/ol0625280

  日期：2007.2.1

  Microwave-promoted, cobalt-catalyzed intramolecular [2 + 2 + 2] cyclizations of dialkynylnitriles successfully gave 5,6,7,8-tetrahydro-1,6-naphthyridines. The efficient synthesis of these relatively simple, yet rarely addressed heterocycles enabled the preparation of a collection of these compounds.