Pyrido[4,3-g]isoquinoline | 51521-30-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: Pyrido[4,3-g]isoquinoline
• CAS: 51521-30-3
• 化学式: C₁₂H₈N₂
• 分子量: 180.2
• InChiKey: KNYFJKORPUITSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• 2'-methoxy substituted oligomeric compounds and compositions for use in gene modulations
  申请人：——

  公开号：US20040147022A1

  公开（公告）日：2004-07-29

  Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′-OCH 3 substituent group on a sugar moiety. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.

  提供了包含第一和第二寡核苷酸的组合物，其中第一寡核苷酸的至少一部分能够与第二寡核苷酸的至少一部分杂交，第一寡核苷酸的至少一部分与所选目标核酸互补并能够杂交，第一或第二寡核苷酸中至少有一个包含修饰糖和/或骨架修饰。在某些实施例中，修饰是在糖基上的2'-OCH3取代基。还提供了寡核苷酸/蛋白质组合物，其中包括与所选目标核酸互补并能够杂交的寡核苷酸和至少一种蛋白质，该蛋白质包括RNA诱导沉默复合物（RISC）的至少一部分，其中至少一核苷酸具有修饰糖和/或骨架修饰。
• 2'-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
  申请人：——

  公开号：US20040171029A1

  公开（公告）日：2004-09-02

  Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′-F substituent group on a sugar moiety. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a modified sugar and/or backbone modification.

  提供了包含第一和第二寡聚物的组合物，其中第一寡聚物的至少一部分能够与第二寡聚物的至少一部分杂交，第一寡聚物的至少一部分与所选的靶标核酸互补且能够杂交，并且第一或第二寡聚物中至少有一个包括修饰的糖和/或骨架修饰。在某些实施例中，修饰是糖基上的2'-F取代基。还提供了包括与所选靶标核酸互补且能够杂交的寡聚物和至少一个包括RNA诱导沉默复合物（RISC）的至少一部分的蛋白质的寡聚物/蛋白质组合物，其中寡聚物的至少一个核苷酸具有修饰的糖和/或骨架修饰。
• 2′-methoxy substituted oligomeric compounds and compositions for use in gene modulations
  申请人：Ionis Pharmaceuticals, Inc.

  公开号：US10478449B2

  公开（公告）日：2019-11-19

  Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′-OCH3 substituent group on a sugar moiety. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.

  提供了包含第一和第二低聚物的组合物，其中第一低聚物的至少一部分能够与第二低聚物的至少一部分杂交，第一低聚物的至少一部分与选定的靶核酸互补并能够与靶核酸杂交，第一或第二低聚物中的至少一种包含修饰的糖和/或骨架修饰。在某些实施方案中，修饰是糖分子上的 2′-OCH3 取代基。还提供了寡聚体/蛋白质组合物，其中包含与所选靶核酸互补并能与之杂交的寡聚体和至少一种包含 RNA 诱导沉默复合体（RISC）至少一部分的蛋白质，其中寡聚体的至少一个核苷酸具有修饰的糖和/或骨架修饰。
• Compositions and methods for modulating RNA
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20020160972A1

  公开（公告）日：2002-10-31

  Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

  本文公开了调节 RNA 活性的组合物和方法。根据优选的实施方案，反义组合物由靶向部分和反应部分组成。反应部分优选由一个或两个咪唑官能团组成，通过连接体与靶向寡核苷酸连接，中间有或没有插层分子。此外，还公开了治疗、诊断和研究方法，以及可制成寡核苷酸的合成核苷和核苷片段。
• 2'-substituted oligomeric compounds and compositions for use in gene modulations
  申请人：——

  公开号：US20040171033A1

  公开（公告）日：2004-09-02

  Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2′ substituent group on a sugar moiety that is not H or OH. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.

  提供了包含第一和第二低聚物的组合物，其中第一低聚物的至少一部分能够与第二低聚物的至少一部分杂交，第一低聚物的至少一部分与选定的靶核酸互补并能够与靶核酸杂交，第一或第二低聚物中的至少一种包含修饰的糖和/或骨架修饰。在某些实施方案中，修饰是糖分子上的 2′取代基，该取代基不是 H 或 OH。还提供了寡聚体/蛋白质组合物，其包含与所选靶核酸互补并能与之杂交的寡聚体和至少一种包含 RNA 诱导沉默复合体（RISC）至少一部分的蛋白质，其中寡聚体的至少一个核苷酸具有修饰的糖和/或骨架修饰。