1-benzyl-4-(piperidin-1-yl)pyridinium chloride | 126630-95-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-benzyl-4-(piperidin-1-yl)pyridinium chloride
• 英文别名: 1-Benzyl-4-(piperidin-1-yl)pyridin-1-ium chloride；1-benzyl-4-piperidin-1-ylpyridin-1-ium;chloride
• CAS: 126630-95-3
• 化学式: C₁₇H₂₁N₂*Cl
• 分子量: 288.82
• InChiKey: CTDHCIWSEUMBEL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.02
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  7.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROARYL COMPOUNDS COMPRISING NITROGEN AND USE THEREOF
  申请人：ImmunoMet Therapeutics, Inc

  公开号：US20170305861A1

  公开（公告）日：2017-10-26

  The present invention relates to heteroaryl compounds comprising nitrogen and use thereof, and more specifically to compounds which exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compounds according to the present invention exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer with a reduced dose compared to that of existing drugs. Accordingly, the compounds can be effectively used for treating various types of cancer, such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, pancreatic cancer, renal cancer, prostate cancer, bladder cancer, and liver cancer, and for inhibiting proliferation of cancer cells and metastasis of cancer.

  本发明涉及含氮的杂环化合物及其使用，更具体地涉及对抑制癌细胞增殖、转移和复发具有显著作用的化合物、其制备方法以及包含其作为活性成分的药物组合物。与现有药物相比，本发明的化合物在减少剂量的情况下具有显著的抑制癌细胞增殖、转移和复发的作用。因此，这些化合物可以有效地用于治疗各种类型的癌症，如子宫癌、乳腺癌、胃癌、脑癌、直肠癌、结直肠癌、肺癌、皮肤癌、血液癌、胰腺癌、肾癌、前列腺癌、膀胱癌和肝癌，并用于抑制癌细胞的增殖和癌症的转移。
• JPH01294746A
  申请人：——

  公开号：JPH01294746A

  公开（公告）日：1989-11-28
• RUBBER LAMINATE
  申请人：Shimizu Toshiharu

  公开号：US20110105668A1

  公开（公告）日：2011-05-05

  Disclosed is a rubber laminate containing an unvulcanized fluororubber composition comprising: (A) fluororubber comprising a terpolymer containing 50 to 60 mol % of a constitutional unit derived from vinylidene fluoride, 20 to 30 mol % of a constitutional unit derived from tetrafluoroethylene, and 10 to 30 mol % of a constitutional unit derived from hexafluoropropene; (B) an oxide and/or hydroxide of a divalent metal; (C) a polyhydroxy aromatic compound; (D) a 2-substituted-4,6-dithiol-s-triazine derivative; (E 1 ) a quaternary phosphonium salt or a tetraalkyl ammonium salt; (E 2 ) 1,8-diazabicyclo[5.4.0]undecene-7 (salt); and (E 3 ) a 5-substituted-1,5-diazabicyclo[4.3.0]-5-nonene (salt). In this rubber laminate, the fluororubber layer and the NBR layer are firmly vulcanization-bonded to each other without impairing various excellent characteristics of the fluororubber constituting the rubber layer.
• US4929686A
  申请人：——

  公开号：US4929686A

  公开（公告）日：1990-05-29
• US8574717B2
  申请人：——

  公开号：US8574717B2

  公开（公告）日：2013-11-05