[4-[4-[二(2-氯乙基)氨基]苯基]-1-羟基-1-膦酰丁基]膦酸 | 104233-81-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: [4-[4-[二(2-氯乙基)氨基]苯基]-1-羟基-1-膦酰丁基]膦酸
• 中文别名: 4-(4-(二(2-氯乙基)氨基)苯基)-1-羟基丁烷-1,1-二膦酸
• 英文名称: 4-(4-(Bis(2-chloroethyl)amino)phenyl)-1-hydroxybutane-1,1-bisphosphonic acid
• 英文别名: [4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxy-1-phosphonobutyl]phosphonic acid
• CAS: 104233-81-0
• 化学式: C₁₄H₂₃Cl₂NO₇P₂
• 分子量: 450.2
• InChiKey: JHBMGZJQVAIXNT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  139
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• POLISHING COMPOSITION, POLISHING METHOD USING SAME, AND METHOD FOR PRODUCING SEMICONDUCTOR DEVICE
  申请人：Fujimi Incorporated

  公开号：EP2693460A1

  公开（公告）日：2014-02-05

  The polishing composition of the present invention contains an oxidizing agent and a scratch-reducing agent represented by general formula (1) or (2) below. In the formulas, X1 and X2 are each independently a hydrogen atom, a hydroxyl group, a carboxyl group, a phosphate group, an alkyl group, an aryl group, an alkyl polyamine group, an alkyl polyphosphate group, an alkyl polycarboxylate group, an alkyl polyaminopolyphosphate group, or an alkyl polyaminopolycarboxylate group.

  本发明的抛光组合物含有一种氧化剂和一种划痕还原剂，由以下通式（1）或（2）表示。 在这些通式中，X1 和 X2 各自独立地为氢原子、羟基、羧基、磷酸基、烷基、芳基、烷基多胺基、烷基多磷酸基、烷基多羧酸基、烷基多胺多磷酸基或烷基多胺多羧酸基。
• Neue 1-Hydroxy-1,1-diphosphonsäureverbindungen, Verf. zu ihrer Herstellung u. pharmakologische Zubereitungen, insb. zur Behandlung von Knochentumoren
  申请人：Henkel Kommanditgesellschaft auf Aktien

  公开号：EP0170896B1

  公开（公告）日：1989-05-24
• VERFAHREN ZUR HERSTELLUNG VON 1-HYDROXY-1, 1-DIPHOSPHONSÄUREVERBINDUNGEN
  申请人：Eucro European Contract Research GmbH & Co. KG

  公开号：EP1370565A2

  公开（公告）日：2003-12-17
• Method of producing 1-hydroxy-1,1-diphosphonic acid compounds
  申请人：——

  公开号：US20040087554A1

  公开（公告）日：2004-05-06

  The invention relates to a method of producing the 1-hydroxy-1,1-diphosphonic acid compounds of general formula (I), and/or the pharmacologically acceptable salts thereof, in which formula R 1 represents hydrogen, OH, NO 2 , Cl, F, Br, C 1 -C 6 alkyl that may be substituted with halogen, amine and/or aminoalkyl, C 1-6 alkoxy, aryl, heteroaryl, a group NR 3 R 4 , wherein R 3 and R 4 may be the same or different and represent hydrogen, C 1 -C 6 alkyl, halogen-substituted alkyl, hydroxy-C 1 -alkyl; R 2 represents hydrogen, halogen, amine that may be substituted, C 1 -C 6 alkyl that may be substituted with halogen, amine and/or aminoalkyl, C 1 -C 6 alkoxy, aryl, heteroaryl; Y represents O, S or NH; Z represents C 1 -C 5 alkylene that may be substituted with amine groups, and m and n are 0 or 1, with the proviso that if n=1, m=1. According to the inventive method, a compound of formula (II), wherein R 1 , R 2 , Y, Z, m and n are defined as above, is reacted with a compound of the formula P(OSiR 5 3 ) 3-p R 6 p , wherein R 5 represents a C 1 -C 4 alkyl group, R 6 represents a C 1 -C 6 alkyloxy group, and p is 0, 1 or 2. The reaction product is hydrolyzed in a manner known pre se and is optionally converted to the corresponding salts.
• US4608368A
  申请人：——

  公开号：US4608368A

  公开（公告）日：1986-08-26