1,3-cyclopentadimethylamine | 5732-92-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,3-cyclopentadimethylamine
• 英文别名: Cyclopentane-1,3-diyldimethanamine；[3-(aminomethyl)cyclopentyl]methanamine
• CAS: 5732-92-3
• 化学式: C₇H₁₆N₂
• mdl: MFCD24497434
• 分子量: 128.217
• InChiKey: HTALOEFRFXMCFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环戊烷-1,3-二甲酸甲酯 在 Al(NMe₂)3 作用下， 330.0 ℃ 、101.33 kPa 条件下， 生成 1,3-cyclopentadimethylamine
  参考文献：
  名称：

  一种连续制备胺类化合物的方法

  摘要：

  本发明公开了一种由酸/酯，氨源，氢气为原料一步反应来连续制备胺类化合物的方法以及该方法使用的催化剂及其制备方法和用途。根据本发明的方法首先将催化剂装填入反应器中，将氢气通入反应器中，并升温至200～500℃活化催化剂1‑6h，活化结束后将反应温度调整至目标反应温度200～500℃，调整反应体系压力0.1MPa～5MPa；将反应原料：酸/酯、氨源连续加入反应器中进行反应，原料与催化剂床层接触后在气体的带动下脱离反应器，进入冷凝器与气液分离器后进入产品储罐，尾气排空。根据本发明的方法能够有效地降低生产能耗，降低生产成本，易于实现工业化生产。

  公开号：

  CN117776829A

文献信息

• [EN] PHOSPHINYL AMIDINE COMPOUNDS, METAL COMPLEXES, CATALYST SYSTEMS, AND THEIR USE TO OLIGOMERIZE OR POLYMERIZE OLEFINS<br/>[FR] COMPOSÉS DE PHOSPHINYLAMIDINE, COMPLEXES DE MÉTAL, SYSTÈMES DE CATALYSEUR, ET LEUR UTILISATION POUR OLIGOMÉRISER OU POLYMÉRISER DES OLÉFINES
  申请人：CHEVRON PHILLIPS CHEMICAL CO

  公开号：WO2011082192A1

  公开（公告）日：2011-07-07

  N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, N2-phosphinyl amidinate metal salt complexes are described. Methods for making N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes are also disclosed. Catalyst systems utilizing the N2-phosphinyl amidine metal salt complexes and N2-phosphinyl amidinate metal salt complexes are also disclosed along with the use of the N2-phosphinyl amidine compounds, N2-phosphinyl amidinates, N2-phosphinyl amidine metal salt complexes, and N2-phosphinyl amidinate metal salt complexes for the oligomerization and/or polymerization of olefins.

  描述了N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物、N2-膦胺酸盐金属盐络合物。还公开了制备N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的方法。还公开了利用N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物的催化剂系统，以及利用N2-膦胺化合物、N2-膦胺酸盐、N2-膦胺金属盐络合物和N2-膦胺酸盐金属盐络合物进行烯烃的寡聚和/或聚合的用途。
• Conjugates of disorazoles and their derivatives with cell-binding molecules, novel disorazole derivatives, processes of manufacturing and uses thereof
  申请人：AEterna Zentaris GmbH

  公开号：EP1900742A1

  公开（公告）日：2008-03-19

  The present invention provides conjugates of disorazoles and their derivatives with cell-binding molecules, such as peptides, proteins, hormones, blood proteins and antibodies. The present invention further provides novel disorazole derivatives and processes of manufacturing such conjugates and disorazole derivatives. These compounds can be used as medicaments for the treatment of physiological and/or pathophysiological conditions in mammals, in particular for the treatment of various tumors.

  本发明提供了二氢异菊烯酮及其衍生物与细胞结合分子（如肽、蛋白质、激素、血液蛋白和抗体）结合的共轭物。本发明还提供了新的二氢异菊烯酮衍生物及制造这些共轭物和二氢异菊烯酮衍生物的方法。这些化合物可用作治疗哺乳动物的生理和/或病理状况，特别是治疗各种肿瘤的药物。
• [EN] GANGLIOSIDE CARBOHYDRATE STRUCTURES AND USES THEREOF<br/>[FR] STRUCTURES CARBOHYDRATES DE GANGLIOSIDES ET LEURS UTILISATIONS
  申请人：REALIST PHARMA INC

  公开号：WO2018112669A1

  公开（公告）日：2018-06-28

  The present invention provides methods and compositions related to multivalent carbohydrate antigen structures comprising cancer or infection associated ganglioside carbohydrate antigens. Said carbohydrate structures may be used to induce immunity against said carbohydrate antigens. In some embodiments, carbohydrate structures may be administered to a subject thereby inducing immunity in the subject, for example, the administration of a vaccine comprising said carbohydrate structure. Also provided are methods to induce an immune response in a subject in need thereof by administering said carbohydrate structure. Further provided are methods of producing an antibody or TCR that bind said carbohydrate antigens.

  本发明提供了与癌症或感染相关的神经节苷脂碳水化合物抗原组成的多价碳水化合物抗原结构的方法和组成物。所述碳水化合物结构可用于诱导免疫反应以对抗所述碳水化合物抗原。在某些实施例中，可将碳水化合物结构注射给受试者，从而在受试者中诱导免疫反应，例如，注射包含所述碳水化合物结构的疫苗。还提供了通过注射所述碳水化合物结构来诱导需要免疫反应的受试者的免疫反应的方法。此外，还提供了制备结合所述碳水化合物抗原的抗体或TCR的方法。
• Conjugates activated by cell surface proteases and therapeutic uses thereof
  申请人：Corvas International, Inc.

  公开号：US20040001801A1

  公开（公告）日：2004-01-01

  Conjugates, compositions and methods for treatment, prevention, or amelioration of one or more symptoms of cell surface protease-related diseases, including MTSP-related, urokinase-type plasminogen activator (uPA) or endotheliase-related diseases, are provided. The conjugates for use in the compositions and methods are peptidic conjugates that contain therapeutic, including cytotoxic, agents.

  本发明提供了用于治疗、预防或缓解细胞表面蛋白酶相关疾病的共轭物、组合物和方法，包括MTSP相关、尿激酶型纤溶酶原激活剂（uPA）或内皮酶相关疾病。用于组合物和方法的共轭物是含有治疗性（包括细胞毒性）药物的肽共轭物。
• PROCESS FOR THE REDUCTIVE AMINATION OF ALDEHYDES AND KETONES
  申请人：Molitor Erich J.

  公开号：US20080167499A1

  公开（公告）日：2008-07-10

  Aldehyde or ketone compounds having more than one carbonyl group are reductively aminated to form a product amine compound having more than one primary amino group. The aldehyde or ketone compound is reacted with the product amine compound in the presence of an alcohol solvent, to form a reaction mixture that contains one or more intermediates. The intermediate is then reductively aminated to form the desired product. This process may produce the desired product in very high yields with low levels of secondary amine impurities.

  具有多个羰基基团的醛或酮化合物通过还原胺化反应形成具有多个一级氨基团的产物胺化合物。在醇溶剂存在下，将醛或酮化合物与产物胺化合物反应，形成含有一个或多个中间体的反应混合物。然后，将中间体还原胺化反应形成所需的产物。该过程可产生高收率且含有低水平的二级胺杂质的所需产物。