7-bromo-4-oxo-1-(2-phenoxybenzyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid | 1617540-11-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-bromo-4-oxo-1-(2-phenoxybenzyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid
• 英文别名: 7-Bromo-4-oxo-1-(2-phenoxybenzyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid；7-bromo-4-oxo-1-[(2-phenoxyphenyl)methyl]-1,5-naphthyridine-3-carboxylic acid
• CAS: 1617540-11-0
• 化学式: C₂₂H₁₅BrN₂O₄
• 分子量: 451.276
• InChiKey: HTJINYKPFIJUFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  79.7
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  ethyl 7-bromo-4-oxo-1-(2-phenoxybenzyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylate 在 甲醇 、 水 作用下， 反应 15.0h， 以17%的产率得到7-bromo-4-oxo-1-(2-phenoxybenzyl)-1,4-dihydro-1,5-naphthyridine-3-carboxylic acid
  参考文献：
  名称：

  NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

  摘要：

  本发明涉及具有通式（V）的化合物，可选地以药学上可接受的盐、溶剂合物、多型体、共药、共晶、前药、互变异构体、外消旋体、对映体或它们的混合物的形式存在，这些化合物在治疗、改善或预防病毒性疾病方面是有用的。此外，还披露了特定的联合疗法。

  公开号：

  US20140194432A1

文献信息

• Substituted naphthyridines for the treatment, amelioration or prevention of a viral disease
  申请人：Savira pharmaceuticals GmbH

  公开号：US09199987B2

  公开（公告）日：2015-12-01

  The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

  本发明涉及一种具有一般式（V）的化合物，可选地以药学上可接受的盐、溶剂合物、多晶形、共药、共晶、前药、互变异构体、外消旋体、对映体或其混合物的形式存在，其在治疗、缓解或预防病毒性疾病方面具有用途。此外，还披露了特定的联合治疗方案。
• Naphthyridinone derivatives and their use in the treatment, amelioration or prevention of a viral disease
  申请人：Savira pharmaceuticals GmbH

  公开号：US20170290834A1

  公开（公告）日：2017-10-12

  The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
• US9199987B2
  申请人：——

  公开号：US9199987B2

  公开（公告）日：2015-12-01
• US9505758B2
  申请人：——

  公开号：US9505758B2

  公开（公告）日：2016-11-29
• [EN] NAPHTHYRIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE<br/>[FR] DÉRIVÉS DE NAPHTHYRIDINONE ET LEUR UTILISATION POUR LE TRAITEMENT, LE SOULAGEMENT OU LA PRÉVENTION D'UNE MALADIE VIRALE
  申请人：SAVIRA PHARMACEUTICALS GMBH

  公开号：WO2014108408A1

  公开（公告）日：2014-07-17

  The present invention relates to a compound having the general formula (V), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.