3-Ethyl-4-dimethylamino-pyridin | 90565-28-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Ethyl-4-dimethylamino-pyridin
• 英文别名: 4-Dimethylamino-3-ethylpyridin；4-(dimethylamino)-3-ethylpyridine；(3-ethyl-pyridin-4-yl)-dimethyl-amine；3-Ethyl-N,N-dimethyl-4-pyridinamine；3-ethyl-N,N-dimethylpyridin-4-amine
• CAS: 90565-28-9
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: FNRBJMADWMWFMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS SPIRO HÉTÉROCYCLIQUES ET PROCÉDÉS D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2022093856A1

  公开（公告）日：2022-05-05

  The present disclosure provides compounds of Formula (I) having activity as inhibitors of G12C mutantKRASprotein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic and colorectal cancers.

  本公开提供具有抑制G12C突变KRAS蛋白活性的式（I）化合物。本公开还提供包含该化合物的药物组合物，用途和治疗某些疾病的方法，例如癌症，包括但不限于肺癌、胰腺癌和结直肠癌。
• A selective acylation process
  申请人：AB LEO

  公开号：EP0138153A2

  公开（公告）日：1985-04-24

  This invention relates to a selective acylation process for the preparation of phenolic N-disubstituted carbamate esters of steroids, comprising reacting in an inert solvent an acylating agent being a carbamoyl halogenide, a 4-(tertiary amino)-pyridine, or a complex thereof, optionally as a part of a polymer and a steroid having at least two free hydroxy groups, where at least one is phenolic and at least one is alcoholic, optionally in the presence of an acid acceptor.

  本发明涉及一种制备类固醇的酚类 N-二取代氨基甲酸酯的选择性酰化工艺，包括在惰性溶剂中使氨基甲酰基卤化物、4-（叔氨基）-吡啶或其复合物的酰化剂（可选择作为聚合物的一部分）与具有至少两个游离羟基的类固醇（其中至少一个是酚基，至少一个是醇基）反应，可选择在有酸接受体存在的情况下进行。
• US4592869A
  申请人：——

  公开号：US4592869A

  公开（公告）日：1986-06-03