N'-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-N,N-dimethyl-formamidine | 186089-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: N'-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-N,N-dimethyl-formamidine
• 英文别名: N'-(4-chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-N,N-dimethylmethanimidamide
• CAS: 186089-58-7
• 化学式: C₁₁H₁₄ClN₃O
• 分子量: 239.705
• InChiKey: QZTLAOWDOQDKEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  37.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N'-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-N,N-dimethyl-formamidine 在 吡啶 、 硫酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 3-异噻唑甲酰胺,N-(4-氯-7,8-二氢-5H-吡喃并[4,3-b]吡啶-3-基)-
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0
• 作为产物：
  描述：

  苯酰胺,N-(1,5,7,8-四氢-4-羰基-4H-吡喃并[4,3-b]吡啶-3-基)- 在 三氯氧磷 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 以90%的产率得到N'-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-N,N-dimethyl-formamidine
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0

文献信息

• Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines
  作者：Makoto Adachi、Takashi Sasatani、Nobuo Chomei、Susumu Takada

  DOI：10.1016/s0040-4039(96)02071-0

  日期：1996.12

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.