N-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-isoxazole-3-carboxamidine | 151225-27-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃吡啶类
• 英文名称: N-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-isoxazole-3-carboxamidine
• 英文别名: N'-(4-chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-1,2-oxazole-3-carboximidamide
• CAS: 151225-27-3
• 化学式: C₁₂H₁₁ClN₄O₂
• 分子量: 278.698
• InChiKey: CYWMFCZTRJZXRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  86.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-isoxazole-3-carboxamidine 以 various solvent(s) 为溶剂， 反应 1.0h， 以88%的产率得到2-(3-isoxazolyl)-3,6,7,9-tetrahydroimidazo[4,5-d]pyrano[4,3-b]pyridine
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0
• 作为产物：
  描述：

  4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-amine 在 吡啶 、 五氯化磷 、 氨 作用下， 以 二氯甲烷 、 异丙醇 为溶剂， 反应 22.0h， 生成 N-(4-Chloro-7,8-dihydro-5H-pyrano[4,3-b]pyridin-3-yl)-isoxazole-3-carboxamidine
  参考文献：
  名称：

  Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines

  摘要：

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(96)02071-0

文献信息

• EP1408041
  申请人：——

  公开号：——

  公开（公告）日：——
• Intermolecular transfer of an alkenyl group in enamines: Application to synthesis of [b]-fused pyridines
  作者：Makoto Adachi、Takashi Sasatani、Nobuo Chomei、Susumu Takada

  DOI：10.1016/s0040-4039(96)02071-0

  日期：1996.12

  A novel intermolecular alkenyl transfer of enamines was developed for the preparation of cycloalkenylaminomethyleneoxazolones, which were thermally cyclized to [b]-fused pyridines in good yields. The functional manipulation of the pyridines provided versatile precursors for further annulation to tricyclic ring systems. Copyright (C) 1996 Elsevier Science Ltd.