Bromo-PEG5-phosphonic acid diethyl ester | 1446282-41-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: Bromo-PEG5-phosphonic acid diethyl ester
• 英文别名: 1-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]-2-[2-(2-diethoxyphosphorylethoxy)ethoxy]ethane
• CAS: 1446282-41-2
• 化学式: C₁₆H₃₄BrO₈P
• 分子量: 465.31
• InChiKey: LVKZCSJHVKMWKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  26
• 可旋转键数：
  21
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• HYDROPHILIC LINKERS FOR ANTIBODY DRUG CONJUGATES
  申请人：REGENERON PHARMACEUTICALS, INC.

  公开号：US20210332080A1

  公开（公告）日：2021-10-28

  Described herein protein drug conjugates and compositions thereof that are useful, for example, for the target-specific delivery of drugs to cells. By administering these compounds, compositions, and conjugates as described herein to specific target cells, side-effects due to non-specific binding phenomena, for example, to non-target cells are reduced. In certain embodiments, compounds, compositions, and conjugates are provided, which include hydrophilic residues in linker-payloads and protein conjugates thereof.