(R)-2-benzyl-1-tritylaziridine | 1008128-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: (R)-2-benzyl-1-tritylaziridine
• 英文别名: (2R)-2-benzyl-1-tritylaziridine
• CAS: 1008128-98-0
• 化学式: C₂₈H₂₅N
• 分子量: 375.513
• InChiKey: IMVPFRJELZSLFA-SCBLGKRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (R)-2-benzyl-1-tritylaziridine 在 三氟乙酸 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 4.0h， 生成 (R)-2-苄基-氮丙啶
  参考文献：
  名称：

  Investigation of a Flexible Enantiospecific Approach to Aziridines

  摘要：

  [GRAPHICS]A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups.

  DOI：

  10.1021/jo7023637
• 作为产物：
  描述：

  phenylmagnesium bromide 、 (S)-(1-tritylaziridin-2-yl)methyl 4-methylbenzenesulfonate 在 copper(I) bromide dimethylsulfide complex 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以90%的产率得到(R)-2-benzyl-1-tritylaziridine
  参考文献：
  名称：

  Investigation of a Flexible Enantiospecific Approach to Aziridines

  摘要：

  [GRAPHICS]A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups.

  DOI：

  10.1021/jo7023637

文献信息

• Investigation of a Flexible Enantiospecific Approach to Aziridines
  作者：Clare E. Jamookeeah、Christopher D. Beadle、Richard F. W. Jackson、Joseph P. A. Harrity

  DOI：10.1021/jo7023637

  日期：2008.2.1

  [GRAPHICS]A flexible approach to functionalized and enantioenriched aziridines has been developed from an intermediate aziridinylmethyl tosylate. This protocol features a Cu-catalyzed Grignard substitution reaction that allows a range of functionalized organic fragments to be incorporated. Moreover, a convenient one-pot procedure is outlined that allows the trityl group to be exchanged for a range of common N-protecting groups.