2-[(E)-(2-Cyanopropan-2-yl)diazenyl]-2-methylbutanenitrile | 58577-20-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-[(E)-(2-Cyanopropan-2-yl)diazenyl]-2-methylbutanenitrile
• 英文别名: 2-(2-cyanopropan-2-yldiazenyl)-2-methylbutanenitrile
• CAS: 58577-20-1
• 化学式: C₉H₁₄N₄
• 分子量: 178.23
• InChiKey: BJMYVWQLSQZONM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  72.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Process for the production of azo compounds
  申请人：FBC LIMITED

  公开号：EP0031645A2

  公开（公告）日：1981-07-08

  There is described a process for the production of a compound of formula I, in which at least one each of Ri, R2 and R3, and of R4, R5 and R6, represents an electron withdrawing group, or one of R1, R2 and R3 together with one of R4, R5 and R6 form a -CO- group, and the remainder of Ri, R2, R3, R4, R5 and R6, which may be the same or different, each represent an electron withdrawing group, alkyl, cycloalkyl, phenyl or phenylalkyl, or R1 and R2, or R4 and R5, and R1 and R4, may together form a -(CH2)n- chain, in which n is a whole number up to 5, the alkyl, cycloalkyl, phenyl or phenylalkyl group or the -(CH2)n,- chain optionally being substituted, which comprises reacting a compound of formula II, in which Ria, R2a and R3a have the same significances as Ri, R2, and R3 above, and some additional significances, with a compound of formula III, in which R4a, R5a and R6a have the same significances as R4, R5 and R6 above, and some additional significances, the reaction being carried out in an aqueous medium in the presence of a base and a surfactant.

  本发明描述了一种生产式 I.化合物的工艺、 其中 Ri、R2 和 R3 以及 R4、R5 和 R6 中至少各有一个代表取电子基团，或 R1、R2 和 R3 中的一个与 R4、R5 和 R6 中的一个共同形成-CO-基团，其余 Ri、R2、R3、R4、R5 和 R6（可以相同或不同）各自代表取电子基团、烷基、环烷基、苯基或苯基烷基、 或 R1 和 R2，或 R4 和 R5，以及 R1 和 R4 可共同形成-(CH2)n-链，其中 n 为不超过 5 的整数、 烷基、环烷基、苯基或苯基烷基或-(CH2)n-链可选择被取代、 其中包括使式 II 的化合物发生反应、 其中 Ria、R2a 和 R3a 具有与上述 Ri、R2 和 R3 相同的意义，以及一些附加意义、 与式 III.化合物 其中 R4a、R5a 和 R6a 具有与上述 R4、R5 和 R6 相同的意义，以及一些附加意义、 反应在有碱和表面活性剂存在的水介质中进行。
• Scaffolded Nucleic Acid Polymer Particles and Methods of Making and Using
  申请人：HINZ Wolfgang

  公开号：US20110195253A1

  公开（公告）日：2011-08-11

  The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
• Methods of Making Libraries of Nucleic Acids Using Porous Particles
  申请人：HINZ Wolfgang

  公开号：US20110195459A1

  公开（公告）日：2011-08-11

  The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
• Particle Arrays and Methods of Making and Using
  申请人：HINZ Wolfgang

  公开号：US20110201523A1

  公开（公告）日：2011-08-18

  The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.
• Methods of Primer Extension Using Porous Particle Supports
  申请人：HINZ Wolfgang

  公开号：US20110201506A1

  公开（公告）日：2011-08-18

  The invention provides particle compositions having applications in nucleic acid analysis. Nucleic acid polymer particles of the invention allow polynucleotides to be attached throughout their volumes for higher loading capacities than those achievable solely with surface attachment. In one aspect, nucleic acid polymer particles of the invention comprise polyacrylamide particles with uniform size distributions having low coefficients of variations, which result in reduced particle-to-particle variation in analytical assays. Such particle compositions are used in various amplification reactions to make amplicon libraries from nucleic acid fragment libraries.