N-[(Z)-indeno[1,2-b]quinoxalin-11-ylideneamino]pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[(Z)-indeno[1,2-b]quinoxalin-11-ylideneamino]pyridine-3-carboxamide
• 化学式: C₂₁H₁₃N₅O
• 分子量: 351.4
• InChiKey: YAPJYJLDOLWXSR-PLRJNAJWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SURVIVIN-TARGETING ANTI-TUMOR AGENTS AND USES THEREOF
  申请人：Indiana University Research and Technology Corporation

  公开号：US20210299123A1

  公开（公告）日：2021-09-30

  Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification.

  本发明揭示了通过给予靶向二聚蛋白survivin的一个或多个化合物来治疗各种癌症的方法。本发明还揭示了包含这些化合物的药物组合物，以及识别靶向致癌二聚蛋白的抗癌化合物的一般方法。可以用于治疗和药物组合物的示例化合物在说明书中公开了化学结构。
• ANTIVIRAL COMPOUNDS AND METHODS OF USE
  申请人：The Regents of the University of Califonia

  公开号：US20150164910A1

  公开（公告）日：2015-06-18

  Methods for treating enteroviral infections in cells are provided. Aspects of the methods include inhibiting the replication of enterovirus or replication of other virus and/or inhibiting cell death in a cell infected with enterovirus or other viruses.
• [EN] ANTIVIRAL COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS ANTIVIRAUX ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV CALIFORNIA

  公开号：WO2013188848A2

  公开（公告）日：2013-12-19

  Methods for treating enteroviral infections in cells are provided. Aspects of the methods include inhibiting the replication of enterovirus or replication of other virus and/or inhibiting cell death in a cell infected with enterovirus or other viruses.