4H-3,1-Benzoxazine | 253-93-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 4H-3,1-Benzoxazine
• CAS: 253-93-0
• 化学式: C₈H₇NO
• 分子量: 133.15
• InChiKey: XAZNOOMRYLFDQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• HETEROCYCLIC COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：US20170158680A1

  公开（公告）日：2017-06-08

  The present invention provides a heterocyclic compound represented by the formula (I), its stereoisomers, or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and their use in preparing a medicament for the prevention and/or treatment of central nervous system disease.

  本发明提供了一种由公式（I）表示的杂环化合物，其立体异构体，或其药用可接受的盐，其药物组合物，以及它们用于制备预防或治疗中枢神经系统疾病的药物。
• SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF
  申请人：Chen Jianxin

  公开号：US20080096903A1

  公开（公告）日：2008-04-24

  Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g., proliferative disorders, including HSP90-mediated disorders. Methods for preparing and using the disclosed compounds are also described.

  披露了含有磺酰氨基的化合物，这些化合物可用作疾病相关靶点的抑制剂，例如热休克蛋白90（HSP90），并且可用于治疗疾病，例如增殖性疾病，包括HSP90介导的疾病。还描述了制备和使用所披露化合物的方法。
• [EN] "COMPOUNDS AS POTENTIAL DYE MOLECULES"<br/>[FR] COMPOSÉS UTILISÉS EN TANT QUE MOLÉCULES DE COLORANT POTENTIELLES
  申请人：LLEAF PTY LTD

  公开号：WO2019028508A1

  公开（公告）日：2019-02-14

  Disclosed herein are a series of compounds based on Formula (I). These compounds comprise perylene core which has been extended with optionally functionalised imidazoles at the 3,4;9,10 positions. The compounds of Formula (I) can be functionalised at two positions on the perylene core, such as the 1,6 or 1,7 positions. Also disclosed herein are compositions comprising said compounds, methods of forming said compounds and potential applications of said compounds, such as applying the compounds as a dye whose absorbance and fluorescence spectrum are red-shifted.

  本文披露了一系列基于化学式(I)的化合物。这些化合物包括带有可选择功能化的咪唑基团的苝芯，该苝芯在3,4;9,10位置进行了扩展。化学式(I)的化合物可以在苝芯的两个位置进行功能化，例如1,6或1,7位置。本文还披露了包含所述化合物的组合物、形成所述化合物的方法以及所述化合物的潜在应用，例如将化合物应用为吸收和荧光光谱向红移的染料。
• N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
  申请人：The Procter & Gamble Company

  公开号：US20040097560A1

  公开（公告）日：2004-05-20

  Compounds of Formula (I) 1 are effective in the treatment of a microbial infection.

  化合物式（I）1在治疗微生物感染方面具有良好的疗效。
• [EN] METHOD FOR PRODUCING 4-NITROIMIDAZOLE COMPOUND<br/>[FR] PROCÉDÉ POUR PRODUIRE UN COMPOSÉ 4-NITROIMIDAZOLE
  申请人：OTSUKA PHARMA CO LTD

  公开号：WO2005077913A1

  公开（公告）日：2005-08-25

  The present invention provides a method for producing a 4-nitroimidazole compound represented by general formula (1) at high yield and at high purity by a safe method causing few dangers such as explosion. The production method of the present invention comprises iodinating a 4-nitroimidazole compound represented by general formula (2): wherein each of X1 and X2 represents a chlorine atom or bromine atom, and then reducing the obtained 5-iodo-4-nitroimidazole compound represented by general formula (3): wherein X2 is the same as defined above.

  本发明提供了一种生产4-硝基咪唑化合物的方法，该化合物由通式（1）表示，该方法可以高产高纯，同时又能够避免像爆炸等危险。该生产方法包括对由通式（2）表示的4-硝基咪唑化合物进行碘化，其中X1和X2分别表示氯原子或溴原子，然后还原所得的5-碘-4-硝基咪唑化合物，该化合物由通式（3）表示，其中X2与上述定义相同。