N~4~-(Butan-2-yl)-N~1~,N~1~-dimethylbenzene-1,4-diamine | 116688-51-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N~4~-(Butan-2-yl)-N~1~,N~1~-dimethylbenzene-1,4-diamine
• 英文别名: 1-N-butan-2-yl-4-N,4-N-dimethylbenzene-1,4-diamine
• CAS: 116688-51-8
• 化学式: C₁₂H₂₀N₂
• mdl: MFCD12091687
• 分子量: 192.3
• InChiKey: UGXYINOQDDOOFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Inhibitors of low molecular weight protein tyrosine phosphatase (LMPTP) and uses thereof
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US11066420B2

  公开（公告）日：2021-07-20

  Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.

  蛋白酪氨酸磷酸酶（PTPs）是新陈代谢和胰岛素信号传导的关键调节因子。作为胰岛素信号转导的负调控因子，低分子量蛋白酪氨酸磷酸酶（LMPTP）是胰岛素抵抗及相关疾病的靶标。本文描述了能够调节低分子量蛋白酪氨酸磷酸酶（LMPTP）活性水平的化合物和组合物，以及使用这些化合物和组合物的方法。
• INHIBITORS OF LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LMPTP) AND USES THEREOF
  申请人：Sanford Burnham Prebys Medical Discovery Institute

  公开号：US20200055875A1

  公开（公告）日：2020-02-20

  Protein tyrosine phosphatases (PTPs) are key regulators of metabolism and insulin signaling. As a negative regulator of insulin signaling, the low molecular weight protein tyrosine phosphatase (LMPTP) is a target for insulin resistance and related conditions. Described herein are compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and compositions, and methods of using these compounds and compositions.
• US4029702A
  申请人：——

  公开号：US4029702A

  公开（公告）日：1977-06-14