{1-[(甲基氨基)甲基]环戊基}甲醇 | 959238-70-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: {1-[(甲基氨基)甲基]环戊基}甲醇
• 英文名称: {1-[(Methylamino)methyl]cyclopentyl}methanol
• 英文别名: [1-(methylaminomethyl)cyclopentyl]methanol
• CAS: 959238-70-1
• 化学式: C₈H₁₇NO
• mdl: MFCD09864433
• 分子量: 143.23
• InChiKey: SULZFQBYJXFVTO-UHFFFAOYSA-N

物化性质

• 沸点：
  214.7±13.0 °C(Predicted)
• 密度：
  0.941±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2922199090
• WGK Germany：
  3

文献信息

• HETEROCYCLIC-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：US20150011532A1

  公开（公告）日：2015-01-08

  Compounds having the following formula: wherein A is, or; and X is N or C—R 7 , or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

  具有以下式子的化合物：其中A是或；而X是N或C—R7，或其对映异构体、顺反异构体或药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。
• TRIAZOLYL-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20150045347A1

  公开（公告）日：2015-02-12

  Compounds having the following formula: (I) wherein: A is an optionally substituted triazole, or a stereoisomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

  具有以下式子的化合物：（I）其中：A是可选择性取代的三唑，或其立体异构体或药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。
• TARGETED DELIVERY OF NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITORS
  申请人：SEATTLE GENETICS, INC.

  公开号：US20190314519A1

  公开（公告）日：2019-10-17

  Compounds and compositions are disclosed in which a NAMPT Drug Unit is linked to a targeting Ligand Unit through a Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.
• QUATERNIZED NICOTINAMIDE ADENINE DINUCLEOTIDE SALVAGE PATHWAY INHIBITOR CONJUGATES
  申请人：SEATTLE GENETICS, INC.

  公开号：US20200197524A1

  公开（公告）日：2020-06-25

  Compounds and compositions are disclosed in which a NAMPT Drug Unit is conjugated to a targeting Ligand Unit through quaternization by a Linker Unit from which a NAMPT inhibitor compound or derivative thereof is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as those of cancer or an autoimmune disease, using the compounds and compositions of the invention are also disclosed.
• US8987311B2
  申请人：——

  公开号：US8987311B2

  公开（公告）日：2015-03-24