3-Cyclohexylpropane-1,2-diamine | 128833-92-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Cyclohexylpropane-1,2-diamine
• CAS: 128833-92-1
• 化学式: C₉H₂₀N₂
• 分子量: 156.27
• InChiKey: MDSKGSOOZVKZMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE
  申请人：Raynham Tony Michael

  公开号：US20090247519A1

  公开（公告）日：2009-10-01

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.

  本发明一般涉及治疗化合物领域，更具体地涉及某些氨基乙基氨基芳基（AEAA）化合物，该化合物在抑制蛋白激酶D（PKD）（例如，PKD1、PKD2、PKD3）方面起作用。本发明还涉及包含这些化合物的药物组合物，以及在体外和体内使用这些化合物和组合物来抑制PKD，并用于治疗由PKD介导的疾病和症状，通过抑制PKD而改善的疾病和症状等，包括增殖性疾病如癌症等。
• Chemokine receptor binding compounds
  申请人：Zhou Yuanxi

  公开号：US20070066624A1

  公开（公告）日：2007-03-22

  The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR4 or CCR5. In one aspect, these compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).

  本发明涉及化学因子受体结合化合物、药物组合物及其使用。更具体地，本发明涉及化学因子受体活性调节剂，优选地为CCR4或CCR5的调节剂。在一个方面，这些化合物表现出对人类免疫缺陷病毒（HIV）感染靶细胞的保护效应。
• Process for the carbonylation of olefinically unsaturated compounds with a palladium catalyst
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0274795A2

  公开（公告）日：1988-07-20

  Process for the carbonylation of olefinically unsaturated compounds with carbon monoxide in the presence of a hydroxyl-group-containing compound, a palladium catalyst, an organic phosphine, an acid with a pKa value < 2, with the exception of halogen acids and carboxylic acids, as promoter, and a catalyst stabilizer according to formulae II and III as specified and catalyst systems used in said process.

  在一种含羟基化合物、一种钯催化剂、一种有机膦、一种 pKa 值小于 2 的酸（卤素酸和羧酸除外）作为促进剂和一种催化剂稳定剂的存在下，用一氧化碳对烯烃类不饱和化合物进行羰基化的工艺，按式 II 和式 III 规定，以及在上述工艺中使用的催化剂体系。
• Process for the preparation of a modified epoxy resin
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0281213A2

  公开（公告）日：1988-09-07

  A process for the preparation of a primary hydroxyl group containing epoxy resin having from 1.5 to 2.5 epoxy groups per molecule by reacting at a temperature of from 100 to 235 °C in the presence of an etherification catalyst a) an epoxy resin having more than 1.5 and at most 2 epoxy groups per molecule and an epoxy group concentration (EGC) of from 1 to 7 eq.kg⁻¹ with b) an aliphatic trihydric primary alcohol having from 5 to 12 carbon atoms, under the proviso that the ratio (R) of epoxy equivalents of reactant a) to hydroxyl equivalents of reactant b) is selected within the range of from (1.2-0.11 EGC) to (1.3+0.12 EGC).

  一种制备每分子具有 1.5 至 2.5 个环氧基团的含一级羟基的环氧树脂的工艺，其方法是在醚化催化剂存在下，在 100 至 235 °C 的温度下，将 a) 每分子具有 1.5 个以上但至多 2 个环氧基团且环氧基团浓度（EGC）为 1 至 7 eq.kg-¹ 的环氧树脂与 b) 具有 5 至 12 个碳原子的脂肪族三水伯醇反应，条件是反应物 a) 的环氧当量与反应物 b) 的羟基当量之比（R）在（1.2-0.11 EGC）至（1.3+0.12 EGC）的范围内选择。
• METALWORKING FLUID COMPOSITION AND METALWORKING PROCESS
  申请人：KYODO YUSHI CO., LTD.

  公开号：EP1892282A1

  公开（公告）日：2008-02-27

  The present invention provides a water-soluble metal-processing oil composition which is excellent in putrefaction resistant properties and sparingly has any bad influence upon global environment and human body and a method for processing metals which makes use of the metal-processing oil composition. The metal-processing oil composition of the invention comprises an amine carrying a linear or branched alkyl group having not less than 4 carbon atoms (component A) in an amount ranging from 0.5 to 20% and an amine carrying a cycloalkyl ring or a benzene ring (component B) in an amount ranging from 0.5 to 20% and the method for processing metals is characterized in that it uses the metal-processing oil composition.

  本发明提供了一种水溶性金属加工油组合物，它具有优异的抗腐烂性能，对全球环境和人体几乎没有任何不良影响，还提供了一种利用该金属加工油组合物加工金属的方法。 本发明的金属加工油组合物包括含有不少于 4 个碳原子的直链或支链烷基的胺 （成分 A），其用量为 0.5 至 20%；以及含有环烷基或苯环的胺（成分 B），其用量为 0.5 至 20%。