7-hydroxy-2-isopropyl-3-p-tolyl-3H-quinazolin-4-one | 871814-53-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 7-hydroxy-2-isopropyl-3-p-tolyl-3H-quinazolin-4-one
• 英文别名: 7-Hydroxy-2-isopropyl-3-(p-tolyl)quinazolin-4(3H)-one；7-hydroxy-3-(4-methylphenyl)-2-propan-2-ylquinazolin-4-one
• CAS: 871814-53-8
• 化学式: C₁₈H₁₈N₂O₂
• 分子量: 294.353
• InChiKey: QIDPEWLCJJBSHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Quinazolinone Derivatives Useful as Vanilloid Antagonists
  申请人：Chen Weichun

  公开号：US20100197705A1

  公开（公告）日：2010-08-05

  There is described a new polymorphic form of 4-(7-Hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile having structural formula I(B) and to a method of preparing it. There is further a process or method for the manufacture of a pharmaceutically active quinazolinone compounds of the formula I wherein the symbols have the meanings given in the description, said process comprising reacting a compound of the formula II, wherein R 4 * is R 1 *—C(═O)— wherein R 1 * is independently selected from the group of meanings of R 1 as defined for a compound of the formula I so that R 1 * and R 1 are identical to or different from each other, or R 4 * is especially H, and R 1 and R 3 , R 5 and R 6 are as defined for a compound of the formula I, or a salt thereof, under simultaneous or sequential condensation and cyclisation conditions with an aniline compound of the formula III, wherein R 2 and m are as defined for a compound of the formula I. Further reactions and related embodiments are also claimed and disclosed.

  本文描述了一种4-(7-羟基-2-异丙基-4-氧代-4H-喹唑啉-3-基)-苯甲腈的新多晶型式I(B)，以及其制备方法。此外，本文还提供了一种制备具有式I中所给符号所表示含义的药物活性喹唑啉酮化合物的过程或方法，该过程包括将式II的化合物与式III的苯胺化合物在同时或顺序缩合和环化条件下反应，其中R4*为R1*—C(═O)—，其中R1*独立地选自于式I化合物所定义的R1的含义组，使得R1*和R1相同或不同，或R4*特别为H，而R1和R3、R5和R6如式I中所定义，或其盐。本文还声明和揭示了进一步的反应和相关实施方式。
• Trisubstituted Quinazolinone Derivatives as Vanilloid Antagonists
  申请人：Bhalay Gurdip

  公开号：US20090082365A1

  公开（公告）日：2009-03-26

  The present invention relates to quinazolinone compounds of the formula wherein R 2 , R 3 , R 5 , R 6 , R 7 and R 8 are as defined in the specification and in the claims, in free form or in salt form, processes for their preparation and their use as pharmaceuticals, particularly in the treatment of disorders ameliorated by administration of TRPV1 antagonists.

  本发明涉及式中的喹唑啉酮化合物，其中R2、R3、R5、R6、R7和R8如规范和权利要求中所定义，在自由形式或盐形式中，其制备过程及其作为药物的用途，特别是在TRPV1拮抗剂治疗改善的疾病中的应用。
• QUINAZOLINONE DERIVATIVES USEFUL AS VANILLOID ANTAGONISTS
  申请人：Ritchie Timothy John

  公开号：US20110195983A1

  公开（公告）日：2011-08-11

  The present invention relates to the use of a quinazolinone compound of the formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and m are as defined in the specification and in the claims, in free form or in salt form, and, where possible, in acid addition salt form, as a vanilloid.

  本发明涉及使用式（I）中R1，R2，R3，R4，R5和m如规范和要求中所定义的喹唑啉酮化合物，以自由形式或盐形式，如可能，以酸加盐形式，作为一种vanilloid。
• Trisubstituted quinazolinone derivatives as vanilloid antagonists
  申请人：Novartis AG

  公开号：EP2305652A2

  公开（公告）日：2011-04-06

  The present invention relates to quinazolinone compounds of the formula wherein R2, R3, R5, R6 R7 and R8 are as defined in the specification and in the claims, in free form or in salt form , as vanilloid antagonists.

  本发明涉及式如下的喹唑啉酮化合物 其中 R2、R3、R5、R6、R7 和 R8 如说明书和权利要求书中所定义，以游离形式或盐形式作为香草素拮抗剂。
• TRISUBSTITUTED QUINAZOLINONE DERIVATIVES AS VANILLOID ANTAGONISTS
  申请人：Novartis AG

  公开号：EP1963283A2

  公开（公告）日：2008-09-03