N-(4-aminocyclohexyl)acetamide | 160357-84-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(4-aminocyclohexyl)acetamide
• CAS: 160357-84-6
• 化学式: C₈H₁₆N₂O
• 分子量: 156.23
• InChiKey: DGCIBJXJCNPBTN-UHFFFAOYSA-N

物化性质

• 沸点：
  330.6±31.0 °C(Predicted)
• 密度：
  1.02±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Kinase inhibitor compounds
  申请人：Liang Congxin

  公开号：US20090076005A1

  公开（公告）日：2009-03-19

  The invention relates to compounds, compositions comprising the compounds, and methods of using the compounds and compound compositions. The compounds, compositions, and methods described herein can be used for the therapeutic modulation of kinase-mediated processes, and treatment of disease and disease symptoms, particularly those mediated by certain kinase enzymes.

  这项发明涉及化合物、包含这些化合物的组合物，以及使用这些化合物和化合物组合物的方法。本文描述的化合物、组合物和方法可用于治疗激酶介导的过程，并治疗疾病和疾病症状，特别是那些由特定激酶酶介导的症状。
• APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
  申请人：Bruncko Milan

  公开号：US20100305122A1

  公开（公告）日：2010-12-02

  Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

  揭示了抑制抗凋亡Bcl-2蛋白活性的化合物，含有这些化合物的组合物以及治疗在其中表达抗凋亡Bcl-2蛋白的疾病的方法。
• [EN] PYRROLOPYRIMIDINECARBOXAMIDES<br/>[FR] PYRROLOPYRIMIDINE CARBOXAMIDES
  申请人：NYCOMED GMBH

  公开号：WO2009106531A1

  公开（公告）日：2009-09-03

  The compounds of Formula (I) wherein R1, R21, R22, R23, R24, Y and R3 have the meanings as given in the description, the salts thereof, the N-oxides of the compounds and the salts thereof and the stereoisomers of the compounds, the salts, the N-oxides of the compounds and the N-oxides of the salts thereof are effective inhibitors of the type 5 phosphodiesterase.

  Formula（I）中的化合物，其中R1、R21、R22、R23、R24、Y和R3的含义如描述中所述，其盐，化合物的N-氧化物及其盐，化合物的立体异构体，盐，化合物的N-氧化物及其盐的N-氧化物是有效的第5型磷酸二酯酶抑制剂。
• [EN] PERHARIDINES AS CDK INHIBITORS<br/>[FR] PERHARIDINES EN TANT QU'INHIBITEURS DE CDK
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2009034411A1

  公开（公告）日：2009-03-19

  The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b] pyridines, to their uses as well as to a process for manufacturing them. The compounds of the invention have the following formula (I), wherein A, B and R1-R5 are defined in the description. The invention founds application, in particular, in the pharmaceutical field.

  本发明涉及三取代或四取代的咪唑[4,5b]吡啶，以及它们的用途和制造过程。本发明的化合物具有以下式子(I)，其中A、B和R1-R5在描述中有定义。本发明主要应用于制药领域。
• PERHARIDINES AS CDK INHIBITORS
  申请人：MEIJER Laurent

  公开号：US20100280065A1

  公开（公告）日：2010-11-04

  The invention relates to trisubstituted or tetrasubstituted imidazo[4,5b]pyridines, to their uses as well as to a process for manufacturing them. The compounds of the invention are imidazo[4,5b]pyridines. The first general synthesis of 3,5,7 imidazo[4,5b]pyridines is disclosed in the description. The invention founds application, in particular, in the pharmaceutical field.

  本发明涉及三取代或四取代咪唑[4,5b]吡啶，以及它们的用途和制造过程。本发明的化合物是咪唑[4,5b]吡啶。在描述中首次披露了3,5,7咪唑[4,5b]吡啶的一般合成方法。本发明特别适用于制药领域。