S(-)-2-amino-6-fluoro-7-hydroxytetraline hydrochloride | 221384-91-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: S(-)-2-amino-6-fluoro-7-hydroxytetraline hydrochloride
• 英文别名: (7S)-7-amino-3-fluoro-5,6,7,8-tetrahydronaphthalen-2-ol;hydrochloride
• CAS: 221384-91-4
• 化学式: C₁₀H₁₂FNO*ClH
• 分子量: 217.671
• InChiKey: VAOUSRKIVDGSIO-QRPNPIFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.77
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  46.2
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Amberlyst A 、 (S)-2-amino-6-fluoro-7-methoxy-1,2,3,4-tetrahydronaphthalene hydrochloride 生成 S(-)-2-amino-6-fluoro-7-hydroxytetraline hydrochloride
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• 2-AMINOTETRALINES AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES
  申请人：——

  公开号：US20020123652A1

  公开（公告）日：2002-09-05

  2-Aminotetralines, a process for their preparation, and pharmaceutical compositions. for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.

  2-氨基四氢噻唑啉，其制备方法和药物组合物，用于预防和治疗炎症病理（尤其是脓毒症）和/或自身免疫病理，其中已确定炎症细胞因子的病因作用。
• 2-aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：US20030158266A1

  公开（公告）日：2003-08-21

  2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.

  2-氨基四氢萘胺、其制备方法和药物组合物，用于预防和治疗炎症性病变（尤其是脓毒性休克）和/或自身免疫性病变，在这些病变中，炎性细胞因子的致病作用已经得到确认。
• [EN] 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES<br/>[FR] 2-AMINOTETRALINES, LEUR PROCEDE DE PREPARATION, ET COMPOSITIONS PHARMACEUTIQUES POUR LA PREVENTION ET LE TRAITEMENT THERAPEUTIQUE DE PATHOLOGIES INFLAMMATOIRES ET/OU AUTO-IMMUNES
  申请人：SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.

  公开号：WO1999015494A1

  公开（公告）日：1999-04-01

  (EN) 2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopathogenic role of inflammatory cytokines has been ascertained.(FR) La présente invention concerne des 2-aminotétralines, leur procédé de préparation, et des compositions pharmaceutiques pour la prévention et le traitement thérapeutique de pathologies inflammatoires (en particulier le choc septique) et/ou auto-immunes dans lesquelles on a constaté le rôle étiopathogène des cytokines inflammatoires.

  该发明涉及2-氨基间甲酰胺、它们的制备方法以及用于预防和治疗炎症病变（尤其是急性脓毒症）和/或自身免疫性疾病药物制剂的药物，这些疾病尤其以炎症介导的因素为特征。
• 2-AMINOTETRALINES, A PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS, FOR THE PREVENTION AND THERAPEUTIC TREATMENT OF INFLAMMATORY AND/OR AUTOIMMUNE PATHOLOGIES
  申请人：Sigma-Tau IndustrieFarmaceutiche Riunite S.p.A.

  公开号：EP1017667A1

  公开（公告）日：2000-07-12
• 2-Amino-6-methyl-7-acetyl-tetraline and pharmaceutical compositions for the prevention and therapeutic treatment of inflammatory and/or autoimmune pathologies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1017667B1

  公开（公告）日：2003-11-19