[(10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 4-nitrobenzoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: [(10R,13R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] 4-nitrobenzoate
• 化学式: C34H49NO4
• 分子量: 535.8
• InChiKey: MCSXGHLTXBACQB-HNFGIKEQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  39
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Implants for localized drug delivery and methods of use thereof
  申请人：The Regents of the University of California

  公开号：US10912933B2

  公开（公告）日：2021-02-09

  Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to a hydrophobic active agent, and a silicone tubing having a wall permeable to the active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein the two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver a hydrophobic active agent to a target tissue, and kits that find use in performing the present method.

  本文提供了一种向目标组织输送疏水活性剂的植入物。该植入物可包括界定第一表面和与第一表面相对的第二表面的支架，其中支架基本上不渗透疏水活性剂，以及具有可渗透活性剂壁的硅胶管，其中硅胶管的第一长度贴在支架的第一表面上，其中硅胶管的两端从第一表面延伸，并且第一长度内的第二长度的硅胶管所勾勒的路径是迂回的。此外，还提供了一种使用植入物向目标组织局部递送疏水活性剂的方法，以及可用于实施本方法的试剂盒。
• Thermochromic/photochromic cosmetic compositions
  申请人：——

  公开号：US20020192247A1

  公开（公告）日：2002-12-19

  Novel thermochromic and/or photochromic compositions are described. The thermochromic compositions include a thermoset resin, cholesterol, water, and dye, while photochromic compositions include a benzene and a binder, such as silica gel. When mixed, the ingredients of the thermochromic and photochromic compositions form chromic cells with an outer shell comprised of either the thermoset resin (in the case of thermochromic compositions) or potassium nitrate (in the case of photochromic compositions). When the chromic compositions are exposed to either a heat or light stimulus, the chromic cells compress to causing the dye within the cells to no longer be visible, thereby creating a color-changing effect.

  本文描述了新型热致变色和/或光致变色组合物。热致变色组合物包括热固性树脂、胆固醇、水和染料，而光致变色组合物包括苯和粘合剂，如硅胶。热致变色组合物和光致变色组合物的成分混合后会形成铬电池，其外壳由热固性树脂（热致变色组合物）或硝酸钾（光致变色组合物）组成。当色素组合物受到热或光的刺激时，色素细胞会压缩，使细胞内的染料不再可见，从而产生变色效果。
• COATINGS FOR IMPLANTABLE MEDICAL DEVICES FOR LIPOSOME DELIVERY
  申请人：Miv Therapeutics Inc.

  公开号：EP2136856A1

  公开（公告）日：2009-12-30
• IMPLANTS FOR LOCALIZED DRUG DELIVERY AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP3183026A1

  公开（公告）日：2017-06-28
• DEVICES FOR NON-CONTACT THERMOGRAPHIC MAPPING OF TISSUE FOR VIABILITY ASSESSMENT AND METHODS OF THEIR USE
  申请人：EMPIRE TECHNOLOGY DEVELOPMENT LLC

  公开号：US20140236020A1

  公开（公告）日：2014-08-21

  Systems and methods for remote thermographic assessment of tissue viability are disclosed. A system may include a controllable source of one or more thermal stimuli to be applied to a tissue, a measurement system to measure a heat response of the tissue before, during, and/or after the application of the thermal stimuli, and an electronic device that may control either one or both of the source of thermal stimuli and the measurement system. The electronic device may also receive tissue thermal response data from the measurement system, and may further calculate a measure of tissue viability. A method of determining tissue viability may include supplying a thermal stimulus to a tissue, receiving, by a measurement device, the thermal response of the tissue to the stimuli, and a comparison of the thermal response data to at least some viability threshold values. The results may be displayed in a graphical manner.