Pentabromochlorocyclohexane is a white solid. (NTP, 1992)
熔点：
374 to 388 °F (NTP, 1992)
溶解度：
less than 0.1 mg/mL at 64° F (NTP, 1992)
计算性质
辛醇/水分配系数(LogP)：
4.4
重原子数：
12
可旋转键数：
0
环数：
1.0
sp3杂化的碳原子比例：
1.0
拓扑面积：
0
氢给体数：
0
氢受体数：
0
ADMET
毒理性
副作用
职业性肝毒素 - 第二性肝毒素：在职业环境中的毒性效应潜力是基于人类摄入或动物实验的中毒案例。
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Chronic toxicity and oncogenicity were evaluated in Fischer 344 rats (86/sex/control group, 50/sex/treated group) orally exposed to 1,2,3,4,5-pentabromo - 6-chlorocyclohexane (PBCC) in the diet for 2 years at 0, 1, 20 and 70 mg/kg/day for females and at 0, 1, 15 and 50 mg/kg/day for males based on the differential toxicity of PBCC to males and females in previous studies. There were significant differences between treated animals and controls in the following: body weights (decreased for both sexes at high-dose levels), and tissue bromine level (increased to plateau at mid- and high-dose levels in liver, fat and serum in approximately equal concentrations). There were significant increases observed in the necropsy histopathology of the colon of high-dose animals of both sexes: hemorrhage, fluid ingesta and mass or polyp formations; polyploid formations, dilatation, hypercellularity and aggregates of cellular debris in intestinal crypts, and primary polyploid adenoma or carcinoma. There were no significant differences between treated animals and controls in the following: palpable masses, mortality, clinical chemistry, hematology, urinalysis, organ weights, or necropsy and histopathology (except for that of the colon).
The distribution of alpha-1,2,3,4,5-pentabromo - 6-chlorocyclohexane (PBCC) as measured by the total bromine content in adipose, liver and kidney tissues was evaluated in male and female CDF Fischer 344 rats (10/sex/group) fed PBCC at concentrations of 0 or 600 mg/kg/day in Purina Laboratory Chow for 91 days. Statistically significant increases in bromine levels were observed in all analyzed tissues of all treated animals (P < 0.05, Dunnett's test) relative to control animals. The bromine levels (ug/g) in the adipose, liver and kidney tissues of male animals (treated/control) were: 93/2.3, 413/3.9 and 810/7.7, respectively; and of female animals: 117/2.4, 429/5.9 and 750/9.4, respectively. The total bromine in these tissues accounted for approximately 2% of the PBCC ingested during the 13 week exposure period. The biological half-life could not be determined from the data obtained from the tests.
Method for producing organic compounds by substituting halogen atoms
申请人：MITSUI CHEMICALS, INC.
公开号：EP1486479A1
公开（公告）日：2004-12-15
The invention pertains to a method in which a halogen atom of an organic compound is replaced with a group derived from a nucleophilic agent, at high yield and high efficiency, by the following method which includes a step of reacting the nucleophilic agent with an organic material having a halogen atom bonded to a carbon atom having four σ bonds, more specifically: a method for producing an organic compound having Q, the method including a step of reacting a compound represented by general formula (2) with an organic starting material having at least one halogen atom bonded to a carbon atom having four σ bonds so as to replace the halogen atom in the organic starting material with Q:
MQa (2)
(wherein M represents an alkali metal atom, an alkali earth metal atom, or a rare earth metal atom; Q represents a moiety of an inorganic acid or an active hydrogen compound derived by eliminating a proton, wherein Q is a halogen atom different from the halogen atom in the organic starting material having the halogen atom bonded to the carbon atom having the four σ bonds; and a represents an integer of 1 to 3) in the presence of a compound represented by general formula (1)
(wherein Z- represents an anion derived by eliminating a proton from an inorganic acid or an active hydrogen compound; R2 is the same or different; R2 each independently represent a C1-C10 hydrocarbon group or two R2 on the same nitrogen atom may be bonded with each other to form a ring with the nitrogen atom).
[EN] HYDROSILYLATION REACTION CURABLE COMPOSITIONS AND METHODS FOR THEIR PREPARATION AND USE<br/>[FR] COMPOSITIONS DURCISSABLES PAR UNE RÉACTION D'HYDROSILYLATION ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
申请人：DOW CORNING
公开号：WO2013000788A1
公开（公告）日：2013-01-03
A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a platinum-ligand complex that can be prepared by reacting a platinum precursor and a ligand.
[EN] ACRYLATE-FUNCTIONAL BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ À FONCTION ACRYLATE, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
申请人：DOW SILICONES CORP
公开号：WO2020142474A1
公开（公告）日：2020-07-09
A method of preparing an acrylate-functional branched organosilicon compound ("compound") is provided, and comprises reacting (A) a branched organosilicon compound and (B) an acrylate compound in the presence of (C) a catalyst, wherein component (A) has the general formula X-Si(R1)3, where X comprises a halogen-functional moiety and each R1 is selected from R and –OSi(R4)3, with the proviso that at least one R1 is –OSi(R4)3; each R4 is selected from R, –OSi(R5)3, and –[OSiR2]mOSiR3; each R5 is selected from R, –OSi(R6)3, and –[OSiR2]mOSiR3; each R6 is selected from R and –[OSiR2]mOSiR3; each R is an independently selected hydrocarbyl group; and 0≤m≤100; with the proviso that at least one of R4, R5 and R6 is –[OSiR2]mOSiR3. The compound prepared by the method, a copolymer comprising the reaction product of the compound and a second compound, a method of forming the copolymer, and a composition comprising the copolymer are each also provided.
Hydrosilylation Reaction Catalysts and Curable Compositions and Methods for Their Preparation and Use
申请人：Dow Corning Corporation
公开号：US20140296468A1
公开（公告）日：2014-10-02
A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains an iron-organosilicon ligand complex that can be prepared by reacting an iron carbonyl compound and an organosilicon ligand.
[EN] BRANCHED ORGANOSILICON COMPOUND, METHOD OF PREPARING SAME, AND COPOLYMER FORMED THEREWITH<br/>[FR] COMPOSÉ D'ORGANOSILICIUM RAMIFIÉ, SON PROCÉDÉ DE PRÉPARATION ET COPOLYMÈRE FORMÉ AVEC CELUI-CI
申请人：DOW SILICONES CORP
公开号：WO2020142370A1
公开（公告）日：2020-07-09
A branched organosilicon compound ("compound") having the general formula (R1)3Si- X-Y is provided. In the formula: each R1 is selected from R and -OSi(R4)3, with the proviso that at least one R1 is -OSi(R4)3; each R is independently a substituted or unsubstituted hydrocarbyl group; each R4 is selected from R, -OSi(R5)3, and -[OSiR2]mOSiR3; each R5 is selected from R, -OSi(R6)3, and -[OSiR2]mOSiR3; each R6 is selected from R and -[OSiR2]mOSiR3; with the proviso that at least one of R4, R5 and R6 is -[OSiR2]mOSiR3; 0
