7-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid | 869947-40-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 7-(Trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid
• CAS: 869947-40-0
• 化学式: C₈H₄F₃N₃O₂
• mdl: MFCD04969252
• 分子量: 231.13
• InChiKey: BGZWQYQWZNUOJO-UHFFFAOYSA-N

物化性质

• 密度：
  1.73±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  67.5
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Identification of stabilizers of multimeric proteins
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US11337935B2

  公开（公告）日：2022-05-24

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.

  本文公开的化合物及其组合物可用于提高 TTR 四聚体的稳定性，减少其折叠错误和形成聚集体的倾向。本文还提供了使用这些化合物和组合物提高 TTR 的稳定性从而减少 TTR 形成聚集体的方法。本文还公开了筛选提高 TTR 稳定性的候选化合物的方法。本文还公开了杂多功能化合物，其中包括通过连接体与靶向分子连接的 TTR 结合化合物，用于破坏靶蛋白的 PPI。
• Identification of Stabilizers of Multimeric Proteins
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20200016098A1

  公开（公告）日：2020-01-16

  Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein.