Synthesis of Chiral Organocatalysts derived from Aziridines: Application in Asymmetric Aldol Reaction
作者:Shikha Gandhi、Vinod K. Singh
DOI:10.1021/jo8019863
日期:2008.12.5
We report the synthesis of a new series of highly efficient chiral organocatalysts derived via the regio- and stereoselective ring opening of chiral aziridines with azide anions. The catalysts have proved to be very efficient for a direct asymmetric aldolreaction, both with cyclic as well as acyclic ketones in brine with 2 mol % of catalyst loading, and afforded the products in excellent yields (up