6-Methyl-1,3-benzothiazole-2,4-diamine | 1071346-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 6-Methyl-1,3-benzothiazole-2,4-diamine
• CAS: 1071346-94-5
• 化学式: C₈H₉N₃S
• mdl: MFCD11695879
• 分子量: 179.24
• InChiKey: ATMSLSAMHWYQBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH
  申请人：The Regents of the University of Michigan

  公开号：US20190183865A1

  公开（公告）日：2019-06-20

  Provided herein are small molecule inhibitors of NSD1, NSD2 and/or NSD3 activity, and methods of use thereof for the treatment of disease, including leukemia, breast cancer, osteosarcoma, lung and prostate cancers and other solid tumors as well as other diseases dependent on the activity of NSD1, NSD2 and/or NSD3.

  本文提供了NSD1、NSD2和/或NSD3活性的小分子抑制剂，以及利用这些抑制剂治疗疾病的方法，包括白血病、乳腺癌、骨肉瘤、肺癌、前列腺癌和其他实体肿瘤，以及其他依赖于NSD1、NSD2和/或NSD3活性的疾病。
• NSD family inhibitors and methods of treatment therewith
  申请人：The Regents of the University of Michigan

  公开号：US11324729B2

  公开（公告）日：2022-05-10

  Provided herein are small molecule inhibitors of NSD1, NSD2 and/or NSD3 activity, and methods of use thereof for the treatment of disease, including leukemia, breast cancer, osteosarcoma, lung and prostate cancers and other solid tumors as well as other diseases dependent on the activity of NSD1, NSD2 and/or NSD3.

  本文提供了NSD1、NSD2和/或NSD3活性的小分子抑制剂及其用于治疗疾病的方法，包括白血病、乳腺癌、骨肉瘤、肺癌和前列腺癌、其他实体瘤以及依赖于NSD1、NSD2和/或NSD3活性的其他疾病。
• [EN] NSD FAMILY INHIBITORS AND METHODS OF TREATMENT THEREWITH<br/>[FR] INHIBITEURS DE LA FAMILLE NSD ET MÉTHODES DE TRAITEMENT COMPRENANT CES DERNIERS
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2019113469A1

  公开（公告）日：2019-06-13

  Provided herein are small molecule inhibitors of NSD1, NSD2 and/or NSD3 activity, and methods of use thereof for the treatment of disease, including leukemia, breast cancer, osteosarcoma, lung and prostate cancers and other solid tumors as well as other diseases dependent on the activity of NSD1, NSD2 and/or NSD3.