11-(Trimethylazaniumyl)undecane-1-thiolate;hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 11-(Trimethylazaniumyl)undecane-1-thiolate;hydrochloride
• 化学式: C14H32ClNS
• 分子量: 281.9
• InChiKey: SLCWLLVFKQHEIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  17
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• POSITIVELY CHARGED NANOPARTICLES, USE THEREOF, AND PREPARATION METHOD THEREOF
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20210130613A1

  公开（公告）日：2021-05-06

  Provided are positively charged nanoparticles and use thereof. According to the nanoparticles of an aspect, cucurbituril may limit electrostatic attraction between a guest for cucurbituril and a metal salt, thereby generating nanoparticles with a uniform size. Accordingly, the nanoparticles may have an effect of being capable of efficient intracellular gene delivery.

  提供了带正电荷的纳米粒子及其用途。根据该方面的纳米粒子，黄瓜环糊精可以限制客体与金属盐之间的静电吸引力，从而产生具有均匀大小的纳米粒子。因此，这些纳米粒子具有能够有效进行细胞内基因传递的效果。
• Method for the preparation of a coating comprising oligomeric alkynes
  申请人：ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) EPFL-TTO

  公开号：US10787576B2

  公开（公告）日：2020-09-29

  The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N)x-(L)m-(C═C)n-(L′)o-(N′)y—R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C)n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C1-C25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis of the monomers according to the invention.

  本发明涉及一种在基底上制备包含至少一个涂层的涂层的方法，该方法包括以下步骤 a.提供R-(N)x-(L)m-(C═C)n-(L′)o-(N′)y-R′类型的单体，其中R是头部分子，R′是尾部分子，(C≡C)n是低碳原子分子，L和L′是连接分子、N和N′独立地是支链或未支链的任选取代的C1-C25烷基，任选含有1至5个杂原子，x、m、o和y独立地是0或1，n是4至12，其中头部分子允许与基质表面相互作用；b.使单体与基底接触，其中单体的头部分子与基底表面的相互作用诱导至少一部分单体以确定的方式排列，从而在表面上形成薄膜，并使单体的低聚酰亚胺分子彼此紧密接触； c. 通过提供外部刺激，诱导低聚酰亚胺分子之间发生反应，使排列的单体至少部分交联，从而在基底上形成涂层。本发明进一步涉及根据本发明方法可获得的涂层、根据本发明方法可获得的涂层的使用、包含根据本发明可获得的涂层的基底以及固体基底的使用。本发明进一步涉及根据本发明合成单体的方法。
• Sensors and methods for capture, killing, and release of bacteria
  申请人：THE UNIVERSITY OF MASSACHUSETTS

  公开号：US11091789B2

  公开（公告）日：2021-08-17

  There is provided a renewable sensor for sensing or selectively capturing a targeted bacteria in a fluid. The renewable sensor includes a surface, the surface includes a substrate, a biologically or bacterially non-adhesive feature disposed on or in functional proximity to at least a portion of the substrate; and an adhesive elements disposed on or in functional proximity to the non-adhesive feature, a flow channel in operative contact with the surface; and a detector configured to detect the targeted cell type captured on the surface. Also provided are method for using the sensor and the surface.

  提供了一种可再生传感器，用于感知或选择性捕获流体中的目标细菌。该可再生传感器包括一个表面，表面包括一个基底、一个设置在基底的至少一部分上或在功能上靠近基底的生物或细菌非粘附特征；以及一个设置在非粘附特征上或在功能上靠近非粘附特征的粘附元件、一个与表面有效接触的流道；以及一个被配置为检测表面上捕获的目标细胞类型的检测器。还提供了使用传感器和表面的方法。
• ENCAPSULATED DYE COATED NOBLE METAL NANOPARTICLES WITH INCREASED SURFACE ENHANCED RAMAN SCATTERING PROPERTIES AS CONTRAST AGENTS
  申请人：Zamecnik, Colin R.

  公开号：EP2932243B1

  公开（公告）日：2020-05-13
• Nanoparticle radiosensitizers
  申请人：Guo Ting

  公开号：US20080003183A1

  公开（公告）日：2008-01-03

  Herein is described Nanostructure Enhanced X-ray Therapy (NEXT), which uses nanomaterials as radiosensitizers to enhance electromagnetic radiation absorption in specific cells or tissues. The nanomaterial radiosensitizers emit Auger electrons and generate radicals in response to electromagnetic radiation, which can cause localized damage to DNA or other cellular structures such as membranes. The nanomaterial radiosensitizers contain moieties for specific targeting to molecules or structures in a cell or tissue, and can be functionalized for increased stability and solubility. The nanomaterial radiosensitizers can also be used as detection agents to help in early diagnosis of disease. Together with known techniques such as Computed Tomography or Computerized Axial Tomography (CT or CAT scan), these nanomaterial radiosensitizers could allow early diagnosis and treatment of diseases such as cancer and HIV.