(S)-2,2'-bis[bis(3,5-dimethylphenyl)phosphinoamino]-1,1'-binaphthyl

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (S)-2,2'-bis[bis(3,5-dimethylphenyl)phosphinoamino]-1,1'-binaphthyl
• 英文别名: N-bis(3,5-dimethylphenyl)phosphanyl-1-[2-[bis(3,5-dimethylphenyl)phosphanylamino]naphthalen-1-yl]naphthalen-2-amine
• 化学式: C₅₂H₅₀N₂P₂
• 分子量: 764.93
• InChiKey: ABBGZONQZFIPNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15
• 重原子数：
  56
• 可旋转键数：
  9
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  [1,1’-联萘]-2,2’-二胺 、 氯二(3,5-二甲基苯基)膦 生成 (S)-2,2'-bis[bis(3,5-dimethylphenyl)phosphinoamino]-1,1'-binaphthyl
  参考文献：
  名称：

  亚膦酰胺配体在钯络合物催化的不对称烯丙基烷基化中的应用：空间效应对对映选择性的影响

  摘要：

  膦配体酰胺1 - 4由2,2-衍生' -二氨基-1,1 '联萘（BINAM）和2,2- '二氨基-5,5 '，6,6 '，7,7 '，8,8 ' -八氢- 1,1 '联萘（H 8 -BINAM）已经被制备和钯配合物催化的不对称烯丙位烷基化应用。外消旋的1，3-二苯基-2-丙烯基乙酸酯与丙二酸酯，α-取代的丙二酸酯或乙酰丙酮的烷基化反应由带有这些配体的钯配合物催化，可以得到高达96％ee的产物。

  DOI：

  10.1016/j.tetasy.2003.10.039

文献信息

• METHOD FOR PREVENTING DECREASE IN OPTICAL PURITY
  申请人：Nara Hideki

  公开号：US20140296582A1

  公开（公告）日：2014-10-02

  The present invention provides a method for producing a reduction reaction product, wherein recovery of the reaction solvent and/or distillation is carried out after adding a nitrogen-containing compound into a reaction liquid of a reduction reaction that has been conducted using a transition metal complex. The present invention is capable of suppressing decrease in the optical purity of the reduction reaction product due to the transition metal complex used as a catalyst.

  本发明提供了一种生产还原反应产物的方法，其中在向使用过渡金属配合物进行的还原反应的反应液中添加含氮化合物后，进行反应溶剂和/或蒸馏的回收。本发明能够抑制由于作为催化剂使用的过渡金属配合物导致的还原反应产物光学纯度降低。
• Rhodium-catalyzed asymmetric hydrogenation with aminophosphine ligands derived from 1,1′-binaphthyl-2,2′-diamine
  作者：Rongwei Guo、Xingshu Li、Jing Wu、Wai Him Kwok、Jian Chen、Michael C.K Choi、Albert S.C Chan

  DOI：10.1016/s0040-4039(02)01510-1

  日期：2002.9

  Chiral ligands 2,2′-bis(dicyclohexylphosphinoamino)-1,1′-binaphthyl and 2,2′-bis[bis(3,5-dimethylphenyl)phosphinoamino]-1,1′-binaphthyl were synthesized by reacting 1,1′-binaphthyl-2,2′-diamine with dicyclohexylchlorophosphine and bis(3,5-dimethylphenyl)chlorophosphine, respectively. Application of these ligands to the Rh-catalyzed asymmetric hydrogenation of a variety of amidoacrylic acids and esters

  通过1,1反应合成手性配体2,2'-双（二环己基膦氨基）-1,1'-联萘基和2,2'-双[双（3,5-二甲基苯基）膦氨基] -1,1'-联萘基′-联萘-2，2′-二胺分别与二环己基氯膦和双（3，5-二甲基苯基）氯膦。这些配体在Rh催化的各种酰胺基丙烯酸和酯的不对称加氢中的应用提供了具有出色对映选择性（高达99％ee和定量收率）的手性氨基酸衍生物。
• PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20150210657A1

  公开（公告）日：2015-07-30

  A process for producing an optically active amine compound, characterized by asymmetrically hydrogenating a prochiral carbon-nitrogen double bond in the presence of a ruthenium complex represented by general formula (1) or (2) (wherein P represents an optically active diphosphine, X represents an anionic group, and Ar represents an optionally substituted arylene group).

  一种制备光学活性胺化合物的方法，其特征在于在存在由通用式（1）或（2）表示的钌配合物的情况下，对一个丙半胱氨基双键进行不对称氢化（其中P代表光学活性二膦，X代表阴离子基团，Ar代表可选择取代的芳基基团）。
• RUTHENIUM COMPLEX AND METHOD FOR PREPARING OPTICALLY ACTIVE ALCOHOL COMPOUND
  申请人：Nara Hideki

  公开号：US20130041151A1

  公开（公告）日：2013-02-14

  The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having ruthenacycle structure, a catalyst for asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol using the ruthenium complex.

  本发明提供了一种新型的钌配合物，该配合物在对羰基化合物的不对称还原反应中具有优异的催化活性和对映选择性，以及使用该钌配合物的催化剂和制备光学活性醇化合物的方法。本发明涉及一种具有钌环结构的钌配合物，一种由该钌配合物组成的不对称还原催化剂，以及使用该钌配合物制备光学活性醇的方法。
• NOVEL RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL COMPOUND USING SAME AS CATALYST
  申请人：Hori Kiyoto

  公开号：US20140187809A1

  公开（公告）日：2014-07-03

  The present invention provides a novel ruthenium complex which has an excellent catalytic activity in terms of reactivity for an asymmetric reduction of a carbonyl compound and enantioselectivity, a catalyst using the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex. The present invention relates to a ruthenium complex having a ruthenacycle structure, a catalyst for an asymmetric reduction consisting of the ruthenium complex, and a method for preparing optically active alcohol compounds using the ruthenium complex.

  本发明提供了一种新型的钌配合物，其在对羰基化合物的不对称还原反应中具有优异的催化活性和对映选择性，还提供了使用该钌配合物制备光学活性醇化合物的催化剂和方法。本发明涉及一种具有钌环结构的钌配合物、用于不对称还原反应的催化剂，以及使用该钌配合物制备光学活性醇化合物的方法。