2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫杂环戊烷
• 英文名称: 2-[(3R)-1,1-dioxothiolan-3-yl]acetohydrazide
• 化学式: C₆H₁₂N₂O₃S
• 分子量: 192.24
• InChiKey: BHPBLQYIHLJARH-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  97.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Alkyl substituted triazole compounds as agonists of the APJ Receptor
  申请人：AMGEN INC.

  公开号：US11191762B2

  公开（公告）日：2021-12-07

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.

  式 I 和式 II 的化合物、其药学上可接受的盐、前述任何化合物的立体异构体或其混合物是 APJ 受体的激动剂，可用于治疗心血管疾病和其他疾病。式 I 和式 II 的化合物具有如下结构：(I)、(II) 变量的定义见本文。
• ALKYL SUBSTITUTED TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20190290647A1

  公开（公告）日：2019-09-26

  Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: (I), (II) where the definitions of the variables are provided herein.