2,2-dimethyl-N-(6-propan-2-yl-1,3-benzothiazol-2-yl)propanamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2,2-dimethyl-N-(6-propan-2-yl-1,3-benzothiazol-2-yl)propanamide
• 化学式: C₁₅H₂₀N₂OS
• 分子量: 276.4
• InChiKey: ZCTAROROKCNIRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compositions and therapeutic methods
  申请人：AyuVis Research LLC

  公开号：US11207343B2

  公开（公告）日：2021-12-28

  The present invention is directed to novel products, variants, pharmaceutically acceptable salts and prodrugs thereof, and medical use of such compounds for the treatment and/or management of sepsis, septicemia, septic shock, ocular infection, ocular inflammation, ocular angiogenesis, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel diseases (IBD), asthma, chronic obstructive pulmonary disease, fever syndromes, cachexia, psoriasis, autoimmune diseases, cardiac diseases, retinoblastoma, cancer and/or any disorder associated with inflammation, immunomodulation and microbial infection.

  本发明涉及其新型产品、变体、药学上可接受的盐类和原药，以及此类化合物在治疗和/或控制败血症、脓毒血症、败血性休克、眼部感染、眼部炎症、眼部血管生成、类风湿性关节炎（RA）、动脉粥样硬化、哮喘、慢性阻塞性肺病、发热综合征、恶病质、银屑病、自身免疫性疾病、心脏疾病、牛皮癣等疾病方面的医学用途、动脉粥样硬化、炎症性肠病（IBD）、哮喘、慢性阻塞性肺病、发热综合征、恶病质、银屑病、自身免疫性疾病、心脏病、视网膜母细胞瘤、癌症和/或任何与炎症、免疫调节和微生物感染相关的疾病。
• COMPOSITIONS AND THERAPEUTIC METHODS
  申请人：AyuVis Research, Inc.

  公开号：US20220143059A1

  公开（公告）日：2022-05-12

  The present invention is directed to novel products, variants, pharmaceutically acceptable salts and prodrugs thereof, and medical use of such compounds for the treatment and/or management of sepsis, septicemia, septic shock, peritonitis, skin and soft tissue infections, ocular infection, ocular inflammation, ocular angiogenesis, rheumatoid arthritis (RA), atherosclerosis, inflammatory bowel diseases (IBD), necrotizing enterocolitis, asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome, acute lung injury, bacterial and viral pneumonia, chronic lung injury, acute kidney injury, chronic kidney injury, fibrosis, fever syndromes, cachexia, psoriasis, autoimmune diseases, cardiac diseases, retinoblastoma, cancer and/or any disorder associated with inflammation, immunomodulation and microbial infection.