N-(2-(2-Hydroxyethoxy)ethyl)-(2-naphthoxy)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-(2-Hydroxyethoxy)ethyl)-(2-naphthoxy)acetamide
• 英文别名: N-[2-(2-hydroxyethoxy)ethyl]-2-naphthalen-2-yloxyacetamide
• 化学式: C₁₆H₁₉NO₄
• 分子量: 289.331
• InChiKey: AJLGLGIMMXBYBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2-萘氧基)醋酸N-羟基丁二酰亚胺酯 、 二甘醇胺 以 二氯甲烷 为溶剂， 反应 3.0h， 以75%的产率得到N-(2-(2-Hydroxyethoxy)ethyl)-(2-naphthoxy)acetamide
  参考文献：
  名称：

  Using affinity capillary electrophoresis to identify the peptide in a peptide library that binds most tightly to vancomycin

  摘要：

  This paper describes a procedure, based on competitive binding, for identifying tight-binding ligand(s) for a receptor in mixtures of equimolar ligand candidates using affinity capillary electrophoresis (ACE). Vancomycin and a small library of 32 peptides were used as a model system to illustrate the procedure. This procedure should be applicable to peptide mixtures of greater complexity than the one used here, as well as to mixtures of nonpeptidic compounds. Limits and limitations to the procedure are described.

  DOI：

  10.1021/jo00055a017

文献信息

• Using affinity capillary electrophoresis to identify the peptide in a peptide library that binds most tightly to vancomycin
  作者：Yen Ho Chu、Luis Z. Avila、Hans A. Biebuyck、George M. Whitesides

  DOI：10.1021/jo00055a017

  日期：1993.1

  This paper describes a procedure, based on competitive binding, for identifying tight-binding ligand(s) for a receptor in mixtures of equimolar ligand candidates using affinity capillary electrophoresis (ACE). Vancomycin and a small library of 32 peptides were used as a model system to illustrate the procedure. This procedure should be applicable to peptide mixtures of greater complexity than the one used here, as well as to mixtures of nonpeptidic compounds. Limits and limitations to the procedure are described.