5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide naphthalene-1,5-disulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide naphthalene-1,5-disulfonate
• 英文别名: 3-(4-chlorophenyl)-2-(2,4-dichlorophenyl)-N-piperidin-1-ium-1-yl-3,4-dihydropyrazole-5-carboxamide;5-sulfonaphthalene-1-sulfonate
• 化学式: C₁₀H₈O₆S₂*2C₂₁H₂₁Cl₃N₄O
• 分子量: 1191.87
• InChiKey: ARNFXNSZJZGXON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  47
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  173
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-piperidin-1-yl-4,5-dihydro-1H-pyrazole-3-carboxamide 、 1,5-萘二磺酸 以 乙酸乙酯 为溶剂， 反应 24.0h， 以79%的产率得到5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H-pyrazole-3-carboxamide naphthalene-1,5-disulfonate
  参考文献：
  名称：

  WO2007/9708

  摘要：

  公开号：

文献信息

• SALTS OF SUBSTITUTTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AND MEDICAMENTS
  申请人：Torrens Jover Antonio

  公开号：US20090149472A1

  公开（公告）日：2009-06-11

  The present invention relates to salts of substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及替代吡唑啉化合物的盐、其制备方法、包含这些化合物的药物以及它们用于制备治疗人类和动物的药物的用途。
• Salts of substituted pyrazoline compounds, their preparation and use as medicaments
  申请人：LABORATORIOS DEL DR. ESTEVE, S.A.

  公开号：EP1749820A1

  公开（公告）日：2007-02-07

  The present invention relates to salts of substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.

  本发明涉及取代吡唑啉化合物的盐、其制备方法、包含这些化合物的药物以及它们在制备治疗人类和动物的药物中的用途。
• SALTS OF SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS
  申请人：Laboratorios del Dr. Esteve S.A.

  公开号：EP1907365A1

  公开（公告）日：2008-04-09
• [EN] SALTS OF SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS<br/>[FR] SELS DE COMPOSES A BASE DE PYRAZOLINE SUBSTITUES, LEUR PREPARATION ET LEUR UTILISATION EN TANT QUE MEDICAMENTS
  申请人：ESTEVE LABOR DR

  公开号：WO2007009708A1

  公开（公告）日：2007-01-25

  [EN] The present invention relates to salts of substituted pyrazoline compounds, methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
  [FR] La présente invention a trait à des sels de composés à base de pyrazoline substitués, à leurs procédés de préparation, à des médicaments comportant lesdits composés ainsi qu'à leur utilisation pour la préparation d'un médicament pour le traitement d'humains et d'animaux.
• WO2007/9708
  申请人：——

  公开号：——

  公开（公告）日：——