(R)-(3,5-dioxa-4-phosphacyclohepta[2,1-α:3,4-α']dinaphthalen-4-yl)-(4-methoxyphenyl)-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R)-(3,5-dioxa-4-phosphacyclohepta[2,1-α:3,4-α']dinaphthalen-4-yl)-(4-methoxyphenyl)-amine
• 英文别名: N-(4-methoxyphenyl)-12,14-dioxa-13-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaen-13-amine
• 化学式: C₂₇H₂₀NO₃P
• 分子量: 437.434
• InChiKey: AVMWHLYVFPTWAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  32
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  47.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (R)-1,1'-Bi-2-naphthol 在 三乙胺 、 三氯化磷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 12.0h， 生成 (R)-(3,5-dioxa-4-phosphacyclohepta[2,1-α:3,4-α']dinaphthalen-4-yl)-(4-methoxyphenyl)-amine
  参考文献：
  名称：

  高效铑/亚磷酰胺催化N，N-二甲基氨磺酰基保护的醛亚胺的不对称芳基化的配体库方法。

  摘要：

  DOI：

  10.1002/anie.200504309

文献信息

• 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED MONOPHOSPHINE LIGAND, INTERMEDATES TEHREOF, PREPARATION METHOD AND USE OF THE SAME
  申请人：ZHEJIANG UNIVERSITY

  公开号：US20210070789A1

  公开（公告）日：2021-03-11

  Provided are a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based monophosphine ligand and intermediates thereof, and preparation methods and uses of the same. The monophosphine ligand is a compound represented by formula I or formula I′, or an enantiomer, a raceme or a diastereoisomer thereof, including phosphonite ligands, phosphite ligands, phosphoramidite ester ligands, phosphoric acid and phosphonic amide. The monophosphine ligand is prepared with a known 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol derivative as a raw material through a scheme in which the compound presented by formula II acts as an intermediate. The present disclosure provides a novel monophosphine ligand, which can be used as a ligand in a metal-catalysed organic reactions or in directly catalyzing an organic reaction, especially as a chiral monophosphine ligand widely used in many chiral catalytic reactions such as asymmetric addition, asymmetric hydrogenation, asymmetric coupling, and asymmetric allyl alkylation, having economic practicality and industrial application prospects.
• 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-7,7'-DIOL
  申请人：ZHEJIANG UNIVERSITY

  公开号：US20220213015A1

  公开（公告）日：2022-07-07

  Provided herein is 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol, which is a compound represented by formula I, or an enantiomer or a raceme thereof. The 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol is prepared with a 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-dicarbaldehyde derivative as a starting material through a Baeyer-Villiger oxidation rearrangement reaction and an alkaline hydrolysis reaction. The 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol comprises two gem-dimethyl groups and is a key intermediate for preparing corresponding 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based monophosphine ligands, such as phosphonite ligands, phosphite ligands, phosphoramidite ester ligands, phosphoric acid and phsophonamidate. The 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-7,7′-diol skeleton provided herein could be used in chemical industry and has economic practicality and industrial application prospects.
• A Ligand-Library Approach to the Highly Efficient Rhodium/Phosphoramidite-Catalyzed Asymmetric Arylation ofN,N-Dimethylsulfamoyl-Protected Aldimines
  作者：Richard B. C. Jagt、Patrick Y. Toullec、Danny Geerdink、Johannes G. de Vries、Ben L. Feringa、Adriaan J. Minnaard

  DOI：10.1002/anie.200504309

  日期：2006.4.21