5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid N'-(1-tert-butyl-3,4,4-trimethylpent-2-enyl)hydrazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid N'-(1-tert-butyl-3,4,4-trimethylpent-2-enyl)hydrazide
• 英文别名: 5-Ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid N'-(1-tert-butyl-3,4,4-trimethyl-pent-2-enyl)-hydrazide；5-ethyl-N'-(2,2,5,6,6-pentamethylhept-4-en-3-yl)-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide
• 化学式: C₂₃H₃₆N₂O₃
• 分子量: 388.55
• InChiKey: AYUVTGKOHFHHQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  59.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-二甲氧基-4-甲基苯甲酰氯 、 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid N'-(1-tert-butyl-3,4,4-trimethylpent-2-enyl)hydrazide 在 potassium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 以38%的产率得到3,5-dimethoxy-4-methylbenzoic acid N-(1-tert-butyl-3,4,4-trimethylpent-2-enyl)-N'-(5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carbonyl)hydrazide
  参考文献：
  名称：

  MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM

  摘要：

  公开号：

  EP1744619B1
• 作为产物：
  描述：

  5-乙基-2,3-二氢-1,4-苯并二氧杂环己烷-6-甲酰肼 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 以 正丁醇 为溶剂， 反应 23.0h， 生成 5-ethyl-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid N'-(1-tert-butyl-3,4,4-trimethylpent-2-enyl)hydrazide
  参考文献：
  名称：

  MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM

  摘要：

  公开号：

  EP1744619B1

文献信息

• Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
  申请人：Palli Reddy Subba

  公开号：US20050266457A1

  公开（公告）日：2005-12-01

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体地说，本发明涉及新颖的替代突变受体及其在核受体为基础的诱导基因表达系统中的应用，以及在宿主细胞中调节基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、基于细胞的高通量筛选分析、功能基因组学和调节转基因生物的性状等应用。
• Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression
  申请人：PALLI Subba Reddy

  公开号：US20120185954A1

  公开（公告）日：2012-07-19

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体而言，本发明涉及新型替代突变受体及其在核受体为基础的诱导基因表达系统中的应用，以及调节宿主细胞基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、细胞基础高通量筛选分析、功能基因组学和转基因生物特征的调节等应用。
• Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System
  申请人：Intrexon Corporation

  公开号：US20140322812A1

  公开（公告）日：2014-10-30

  This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

  本发明涉及生物技术或遗传工程领域。具体而言，本发明涉及基因表达领域。更具体地说，本发明涉及新颖的替换突变受体及其在核受体为基础的可诱导基因表达系统中的应用，以及调节宿主细胞中基因表达的方法，用于基因治疗、大规模蛋白质和抗体生产、基于细胞的高通量筛选分析、功能基因组学和调控转基因生物特征等应用。
• MUTANT RECEPTORS AND THEIR USE IN A NUCLEAR RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM
  申请人：Intrexon Corporation

  公开号：EP1744619B1

  公开（公告）日：2015-10-21