N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazine
• 英文别名: N-[(E)-(3-methylphenyl)methylideneamino]-6-morpholin-4-yl-2-(2-morpholin-4-ylethoxy)pyrimidin-4-amine
• 化学式: C₂₂H₃₀N₆O₃
• 分子量: 426.519
• InChiKey: BAEPYOBCPOCLMI-HAVVHWLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  84.3
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazine 、 甲烷磺酸 以 甲苯 为溶剂， 反应 0.03h， 以94%的产率得到N-(3-methyl-benzylidene)-N'-[6-morpholin-4-yl-2-(2-morpholin-4-yl-ethoxy)-pyrimidin-4-yl]-hydrazine dimesylate
  参考文献：
  名称：

  [EN] DISALT INHIBITORS OF IL-12 PRODUCTION
  [FR] INHIBITEURS DISEL DE PRODUCTION D'IL-12

  摘要：

  公开号：

  WO2005112938A3

文献信息

• DISALT INHIBITORS OF IL-12 PRODUCTION
  申请人：Kostik Elena

  公开号：US20100227860A1

  公开（公告）日：2010-09-09

  This invention relates to disalt nitrogen-heteroaryl inhibitors of IL-12 production, and related methods and pharmaceutical compositions.
• METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS
  申请人：BIOMARIN PHARMACEUTICAL INC.

  公开号：US20180092923A1

  公开（公告）日：2018-04-05

  Described herein are methods using compounds of Formula (I), (Ia), and (Ib) to treat or prevent a lysosomal storage disorder, methods of making such compounds, and methods of using pharmaceutical compositions and medicaments containing such compounds.
• US7745436B2
  申请人：——

  公开号：US7745436B2

  公开（公告）日：2010-06-29
• [EN] METHODS FOR TREATING LYSOSOMAL STORAGE DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DES TROUBLES DU STOCKAGE LYSOSOMAL
  申请人：BIOMARIN PHARM INC

  公开号：WO2016168420A1

  公开（公告）日：2016-10-20

  Described herein are methods using compounds of Formula (I), (Ia), and (Ib) to treat or prevent a lysosomal storage disorder, methods of making such compounds, and methods of using pharmaceutical compositions and medicaments containing such compounds.
• [EN] DISALT INHIBITORS OF IL-12 PRODUCTION<br/>[FR] INHIBITEURS DISEL DE PRODUCTION D'IL-12
  申请人：SYNTA PHARMACEUTICALS CORP

  公开号：WO2005112938A3

  公开（公告）日：2006-05-04