5-[3-(methacryloylaminopropyl)thioureidyl] fluorescein

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 5-[3-(methacryloylaminopropyl)thioureidyl] fluorescein
• 英文别名: N-methacryloylaminopropyl fluorescein thiourea；2-(3-Hydroxy-6-oxoxanthen-9-yl)-5-[3-(2-methylprop-2-enoylamino)propylcarbamothioylamino]benzoic acid；2-(3-hydroxy-6-oxoxanthen-9-yl)-5-[3-(2-methylprop-2-enoylamino)propylcarbamothioylamino]benzoic acid
• 化学式: C₂₈H₂₅N₃O₆S
• 分子量: 531.589
• InChiKey: BDWVVOXNLUOCJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  38
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  169
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  地塞米松 、 N-(2-羟基丙基)甲基丙烯酰胺 、 5-[3-(methacryloylaminopropyl)thioureidyl] fluorescein 生成 P-Dex
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Bone fracture repair by targeting of agents that promote bone healing
  申请人：Purdue Research Foundation Office of Technology Commercialization

  公开号：US10279044B2

  公开（公告）日：2019-05-07

  Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.

  本公开的各个方面一般涉及用于靶向治疗和愈合骨折的化合物。其中一些化合物包括带负电荷的寡肽，该寡肽由酸性寡肽、连接体（可水解或可作为蛋白酶 cathepsin K 的底物）和至少一种促进骨愈合的分子组成。在某些化合物中，促进骨愈合的分子是抑制 GSK3β 的同化化合物，在某些化合物中，促进骨折愈合的分子是促炎剂，如 PGE1。其他实施方案包括治疗骨折的方法，包括施用治疗量的本文公开的任一种化合物。
• BONE FRACTURE REPAIR BY TARGETING OF AGENTS THAT PROMOTE BONE HEALING
  申请人：Kopecek Jindrich

  公开号：US20180147286A1

  公开（公告）日：2018-05-31

  Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.
• [EN] BONE FRACTURE REPAIR BY TARGETING OF AGENTS THAT PROMOTE BONE HEALING<br/>[FR] RÉPARATION DE FRACTURE OSSEUSE PAR CIBLAGE D'AGENTS QUI STIMULENT LA CICATRISATION OSSEUSE
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：WO2016196400A1

  公开（公告）日：2016-12-08

  Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.