filifolinol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: filifolinol
• 英文别名: methyl (2S,3'S,6'R)-3'-hydroxy-2',2',6'-trimethylspiro[3H-1-benzofuran-2,1'-cyclohexane]-5-carboxylate
• 化学式: C₁₈H₂₄O₄
• 分子量: 304.386
• InChiKey: BGEVVKDFAMDZGO-PSZVPEGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  filifolinol 在 吡啶 、 4-二甲氨基吡啶 、 四(三苯基膦)钯 、 双氧水 、 碘 、 silver nitrate 、 溶剂黄146 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.75h， 生成 (1'S,3'S,6'R)-3'-hydroxy-7-(carboxyl)-2',2',6'-trimethyl-3H-spiro[1-benzofuran-2,1'-cyclohexane]-5-carboxylic acid
  参考文献：
  名称：

  Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH

  摘要：

  A series of carboxylic acids carrying various functionalization on C-7 of their common 3H-spiro [benzofuran-2,1'-cyclohexane] skeleton were synthesized from filifolinol, as analogs of the natural Complement inhibitor K-76 COOH. In order to probe the relevance of the C-7 functionalization on their bioactivity, the ability of the analogs to inhibit Complement activation through the classical pathway was determined. The observed results suggest that functionalization of C-7 can modulate the inhibitory activity of the tested compounds. The 7-trifluoromethyl derivative was the compound with the lowest IC50 value among the tested analogs (IC50 = 100 mu M), being more potent than K-76 COOH (IC50 = 570 mu M). (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.07.003

文献信息

• Synthesis and classical pathway Complement inhibitory activity of C7-functionalized filifolinol derivatives, inspired in K-76 COOH
  作者：Enrique L. Larghi、María A. Operto、Rene Torres、Teodoro S. Kaufman

  DOI：10.1016/j.ejmech.2012.07.003

  日期：2012.9

  A series of carboxylic acids carrying various functionalization on C-7 of their common 3H-spiro [benzofuran-2,1'-cyclohexane] skeleton were synthesized from filifolinol, as analogs of the natural Complement inhibitor K-76 COOH. In order to probe the relevance of the C-7 functionalization on their bioactivity, the ability of the analogs to inhibit Complement activation through the classical pathway was determined. The observed results suggest that functionalization of C-7 can modulate the inhibitory activity of the tested compounds. The 7-trifluoromethyl derivative was the compound with the lowest IC50 value among the tested analogs (IC50 = 100 mu M), being more potent than K-76 COOH (IC50 = 570 mu M). (C) 2012 Elsevier Masson SAS. All rights reserved.